Patients with glioblastoma (GBM) have a universally poor prognosis and are in urgent need
of effective treatment strategies. Recent advances in sequencing techniques unraveled the …

Leptomeningeal metastasis is an uncommon and typically late complication of cancer with a
poor prognosis and limited treatment options. Diagnosis is often challenging, with …

Purpose: Approximately one-third of patients with non–small cell lung cancer (NSCLC)
harboring tumors with EGFR-tyrosine kinase inhibitor (TKI)-sensitizing mutations (EGFRm) …

Introduction: Many patients with oncogene-driven non–small-cell lung cancer (NSCLC)
treated with tyrosine kinase inhibitors experience limited sites of disease progression. This …

Since cloning of the ATP-binding cassette (ABC) family member breast cancer resistance
protein (BCRP/ABCG2) and its characterization as a multidrug resistance efflux transporter …

Brain metastases (BM) occur frequently in many cancers, particularly non–small cell lung
cancer (NSCLC), breast cancer, and melanoma. The development of BM is associated with …

Purpose Several cases have been reported in which central nervous system (CNS)
metastases of non-small cell lung cancer (NSCLC) resistant to gefitinib were improved by …

Introduction: Human ATP-binding cassette (ABC) transporters act as translocators of
numerous substrates across extracellular and intracellular membranes, thereby contributing …

Despite aggressive treatment with radiation and chemotherapy, recurrence of glioblastoma
multiforme (GBM) is inevitable. The objective of this study was to show that the blood-brain …

Tyrosine kinases (TKs) are involved in key signaling events/pathways that regulate cancer
cell proliferation, apoptosis, angiogenesis and metastasis. Deregulated activity of TKs has …