Kinase activity plays an essential role in the regulation of immune cell defenses against
pathogens. The protein kinase CK2 (formerly casein kinase II) is an evolutionarily conserved …

Serine/threonine protein kinases (CK2, PIM-1, RIO1) are constitutively active, highly
conserved, pleiotropic, and multifunctional kinases, which control several signaling …

A series of novel iodinated benzimidazoles have been prepared by iodination of respective
benzimidazole with iodine and periodic acid in sulfuric acid solution. Additionally several 2 …

Novel treatments for neurodegenerative disorders are in high demand. It is imperative that
new protein targets be identified to address this need. Characterization and validation of …

Sepsis-induced acute kidney injury (AKI) is a common complication in critically ill patients,
often resulting in high rates of morbidity and mortality. Previous studies have demonstrated …

Objective Intracerebral hemorrhage (ICH) is a common cerebrovascular disease with high
incidence, disability, and mortality. Casein kinase 2 (CK2) is a serine/threonine kinase with …

Objectives: Sepsis is a complex clinical condition associated with high morbidity and
mortality. A distinctive feature of sepsis is the reduced capacity of leukocytes to release …

Activation of casein kinase 2 (CK2) is closely linked to the body disturbance of carbohydrate
metabolism and inflammatory reaction. The renal chronic inflammatory reaction in the setting …

In this article, the derivatives of 3-quinoline carboxylic acid were studied as inhibitors of
protein kinase CK2. Forty-three new compounds were synthesized. Among them 22 …

Breast cancer metastasis suppressor 1 (BRMS1) is decreased in non–small cell lung cancer
(NSCLC) and other solid tumors, and its loss correlates with increased metastases. We …