Methods A panel was assembled consisting of German rheumatology experts, two patient
representatives from the German national patient organization Rheumaliga, and a delegate …

Background The individual contribution of genes in the HLA region to the risk of developing
type 1 diabetes (T1D) is confounded by the high linkage disequilibrium (LD) in this region …

Casein kinase II (CK2) is an enzyme with pleiotropic kinase activity that catalyzes the
phosphorylation of lots of substrates, including STAT3, p53, JAK2, PTEN, RELA, and AKT …

The aim of this study was to formulate and characterize CK2 inhibitor-loaded alginate
microbeads via the polymerization method. Different excipients were used in the formulation …

Mycobacterium tuberculosis uses multiple mechanisms to avoid elimination by the immune
system. We have previously shown that M. tuberculosis can inhibit selected macrophage …

The role of protein kinases p38 and CK2 (casein kinase II) in the response of RAW 264.7
macrophages to the lipopolysaccharide (LPS) from gram-negative bacteria was studied …

Chagas disease, the clinical presentation of T. cruzi infection, is a major human health
concern. While the acute phase of Chagas disease is typically asymptomatic and self …

Chagas disease, endemic from Latin America, is caused by Trypanosoma cruzi and is
transmitted by triatomine feces. This parasite undergoes complex morphological changes …

Protein kinase CK2 comprises two catalytic subunits (42 kDa α and 38 kDa α′) linked
through two regulatory subunits (28 kDa β) existing as αα′ β2 or α2β2 or α′ 2β2 …

IκBβis an inhibitor of nuclear factor kappa B (NF-κB) and participates in the cardiac response
to sepsis. However, the role of the hypo-phosphorylated form of IκBβ at Ser313, which can …