Disruption of normal mucociliary clearance in the airways is undesirable due to the
associated risk of increased respiratory disease. Accordingly, pharmaceutical formulations …

Macromolecular drugs, either free or complexed with colloidal drug carriers, have created a
great deal of interest during the last decade. If one wants to administer these new …

The paper by HOHLFELD et al.[1] in this issue shows that, in rats, bronchoconstriction due to
inhaled acetylcholine is inhibited by inhaled aerosols of surfactant. Bronchoconstriction was …

Widdicombe, John. Airway and alveolar permeability and surface liquid thickness: theory. J.
Appl. Physiol. 82 (1): 3–12, 1997.—The thickness of airway surface liquid (ASL) can be …

Biologic markersâ€" indicators of biological exposure or changeâ€" offer the promise of
early detection of disease caused by environmental exposure. Researchers have used …

Background: Although there is a high incidence of nasal disorders including chronic
sinusitis, there is limited success in the topical drug delivery to the nose and the paranasal …

The vagina has been targeted as the site for delivery of a variety of drugs, and several
different delivery systems have been utilized for this purpose. The compounds have almost …

This article attempts to summarize the factors that influence drug deposition, retention and
absorption within the lung, concentrating particularly on therapeutic aerosols rather than …

The use of pulmonary exogenous surfactant as a vehicle for intratracheally administered
antibiotics to improve local antimicrobial therapy has been proposed. The present study …

New measures are needed to rapidly assess emerging treatments for cystic fibrosis (CF)
lung disease. Using an imaging approach, we evaluated the absorptive clearance of the …