Introduction The locus coeruleus (LC) undergoes extensive neurodegeneration in early
Alzheimer's disease (AD). The LC is implicated in regulating the sleep–wake cycle …

Many believe that engaging in novel and mentally challenging activities promotes brain
health and prevents Alzheimer's disease in later life. However, mental stimulation may also …

The locus coeruleus (LC) is a nucleus in the brain stem producing noradrenaline. While
cognitive decline in Alzheimer's disease (AD) has primarily been related to cholinergic …

Vagus Nerve Stimulation (VNS) is an adjunctive treatment for patients suffering from
inoperable drug-resistant epilepsy. Although a complete understanding of the mediators …

The locus coeruleus (LC) provides the primary noradrenergic inputs to the cerebral cortex.
Despite numerous animal studies documenting the functions of the LC, research in humans …

Noradrenergic and dopaminergic neurons are involved in cognitive functions, relate to
behavioral and psychological symptoms in dementia and are affected in Alzheimer's …

The locus coeruleus (LC) is a brainstem nucleus involved in important cognitive functions.
Recent developments in neuroimaging methods and scanning protocols have made it …

Locus coeruleus (LC) is the main noradrenergic (NA) nucleus of the central nervous system.
LC degenerates early during Alzheimer's disease (AD) and NA loss might concur to AD …

Background We aimed to investigate neuromelanin‐sensitive magnetic resonance imaging
(NM‐MRI) features in the locus coeruleus of de novo Parkinson's disease patients with …

The noradrenergic theory of Cognitive Reserve (Robertson, 2013–2014) postulates that the
upregulation of the locus coeruleus—noradrenergic system (LC–NA) originating in the …