Abstract Purpose of Review Performing a thorough review of magnetic resonance imaging
(MRI) studies assessing locus coeruleus (LC) integrity in ageing and Alzheimer's disease …

There is clear, early noradrenergic dysfunction in Alzheimer's disease. This is likely
secondary to pathological tau deposition in the locus coeruleus, the pontine nucleus that …

Recent evidence showing degeneration of the noradrenergic system in the locus coeruleus
(LC) in Alzheimer's disease (AD) has motivated great interest in noradrenaline (NA) as a …

Dementia as one of the most prevalent diseases urges for a better understanding of the
central mechanisms responsible for clinical symptoms, and necessitates improvement of …

The locus coeruleus (LC) is the major source of noradrenaline, which plays a key role in
cognition. We aimed to detect the extent of the LC signal attenuation in Alzheimer's disease …

Background: Neuropathological studies have suggested the tau pathology observed in
Alzheimer's disease (AD) originates in brainstem nuclei, but no studies to date have …

Acrylamide (ACR), a recognized neurotoxicant in humans and experimental animals, is
widely used in industry and in food generated through Maillard reaction. Nuclear factor …

Current diagnosis of Alzheimer's disease (AD) relies on a combination of
neuropsychological evaluations, biomarker measurements and brain imaging …

Alzheimer's disease (AD) is the most common form of dementia. It was first described more
than a century ago, and scientists are acquiring new data and learning novel information …

Catecholaminergic transmission plays an essential role in both physiological and
pathological cognitive functions. Plastic changes subserving learning and memory …