Vascular calcification mechanisms: updates and renewed insight into signaling pathways involved in high phosphate-mediated vascular smooth muscle cell …

N Abbasian - Biomedicines, 2021 - mdpi.com
Vascular calcification (VC) is associated with aging, cardiovascular and renal diseases and
results in poor morbidity and increased mortality. VC occurs in patients with chronic kidney …

[HTML][HTML] Vascular calcification in chronic kidney disease: an update and perspective

SC Ren, N Mao, S Yi, X Ma, JQ Zou, X Tang… - Aging and …, 2022 - ncbi.nlm.nih.gov
Chronic kidney disease is a devastating condition resulting from irreversible loss of nephron
numbers and function and leading to end-stage renal disease and mineral disorders …

[HTML][HTML] Vascular calcification in chronic kidney disease: distinct features of pathogenesis and clinical implication

JS Kim, HS Hwang - Korean circulation journal, 2021 - synapse.koreamed.org
Chronic kidney disease (CKD) is associated with a higher prevalence of vascular
calcification (VC) and cardiovascular disease. VC in CKD patients showed different …

The protective role of Klotho in CKD-associated cardiovascular disease

X Bi, K Yang, B Zhang, J Zhao - Kidney Diseases, 2020 - karger.com
Abstract Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity
and mortality in advanced CKD. The major pathological changes of CKD-associated CVD …

Potential actions of baicalein for preventing vascular calcification of smooth muscle cells in vitro and in vivo

E Sulistyowati, JH Hsu, SJ Lee, SE Huang… - International Journal of …, 2022 - mdpi.com
Vascular calcification (VC) is associated with cardiovascular disease. Baicalein, a natural
flavonoid extract of Scutellaria baicalensis rhizome has several biological properties which …

Up-regulation of heme oxygenase-1 by celastrol alleviates oxidative stress and vascular calcification in chronic kidney disease

X Yang, A Chen, Q Liang, Q Dong, M Fu, X Liu… - Free Radical Biology …, 2021 - Elsevier
Vascular calcification is very commonly observed in patients with chronic kidney disease
(CKD), but there is no efficient therapy available. Oxidative stress plays critical roles in the …

NRF2‐suppressed vascular calcification by regulating the antioxidant pathway in chronic kidney disease

D Jin, L Lin, Y Xie, M Jia, H Qiu, K Xun - The FASEB Journal, 2022 - Wiley Online Library
Vascular calcification (VC), in which vascular smooth muscle cells (VSMCs) undergo
differentiation and osteogenic transition, is a common complication of chronic kidney …

Se deficiency induces renal pathological changes by regulating selenoprotein expression, disrupting redox balance, and activating inflammation

S Li, Q Zhao, K Zhang, W Sun, X Jia, Y Yang, J Yin… - Metallomics, 2020 - academic.oup.com
Selenium (Se) is closely associated with kidney disease, and renal injury often occurs
together with hyposelenemia. This study was designed to reveal the mechanism underlying …

Vascular calcification in CKD: New insights into its mechanisms

N Ding, Y Lv, H Su, Z Wang, X Kong… - Journal of Cellular …, 2023 - Wiley Online Library
Vascular calcification (VC) is a common complication of chronic kidney disease (CKD) and
contributes to an increased risk of cardiovascular morbidity and mortality. However, effective …

Overview of multifunctional cysteinyl cathepsins in atherosclerosis-based cardiovascular disease: from insights into molecular functions to clinical implications

XW Cheng, M Narisawa, H Wang, L Piao - Cell & Bioscience, 2023 - Springer
Cysteinyl cathepsins (CTSs) are widely known to have a proteolysis function that mediates
recycling of unwanted proteins in endosomes and lysosomes, and investigation of CTSs has …