Altered intestinal ACE2 levels are associated with inflammation, severe disease, and response to anti-cytokine therapy in inflammatory bowel disease

AA Potdar, S Dube, T Naito, K Li, G Botwin… - Gastroenterology, 2021 - Elsevier
Background And Aims The host receptor for severe acute respiratory syndrome coronavirus
2, angiotensin-converting enzyme 2 (ACE2), is highly expressed in small bowel (SB). Our …

[HTML][HTML] Diagnostic and predictive value of immune-related genes in Crohn's disease

B Yu, Y Yin, Y Tang, K Wei, Z Pan, KZ Li… - Frontiers in …, 2021 - frontiersin.org
Abnormal immune cell infiltration is associated with the pathogenesis of Crohn's disease
(CD). This study aimed to determine the diagnostic and predictive value of immune-related …

[HTML][HTML] Multi-omics data analysis identifies prognostic biomarkers across cancers

E Demir Karaman, Z Işık - Medical Sciences, 2023 - mdpi.com
Combining omics data from different layers using integrative methods provides a better
understanding of the biology of a complex disease such as cancer. The discovery of …

[HTML][HTML] Reduced expression of COVID-19 host receptor, ACE2 is associated with small bowel inflammation, more severe disease, and response to anti-TNF therapy …

AA Potdar, S Dube, T Naito, G Botwin, T Haritunians… - medRxiv, 2020 - ncbi.nlm.nih.gov
Abstract Angiotensin-Converting Enzyme 2 (ACE2) has been identified as the host receptor
for SARS-coronavirus 2 (SARS-CoV-2) which has infected millions world-wide and likely …

[HTML][HTML] Identification of novel core genes involved in Malignant transformation of inflamed colon tissue using a computational biology approach and verification in …

AV Markov, IA Savin, MA Zenkova… - International journal of …, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a complex and multifactorial systemic disorder of the
gastrointestinal tract and is strongly associated with the development of colorectal cancer …

[HTML][HTML] MicroRNA-200c-5p targets NIMA Related Kinase 7 (NEK7) to inhibit NOD-like receptor 3 (NLRP3) inflammasome activation, MODE-K cell pyroptosis, and …

G Wu, D Zhang, L Yang, Q Wu, L Yuan - Molecular immunology, 2022 - Elsevier
Inflammatory bowel disease (IBD), including Crohn's disease (CD) and ulcerative colitis
(UC), is characterized by chronic inflammation of the lower gastrointestinal tract with …

[HTML][HTML] Bioinformatics analysis of differentially expressed genes and protein–protein interaction networks associated with functional pathways in ulcerative colitis

F Cao, YS Cheng, L Yu, YY Xu… - Medical Science Monitor …, 2021 - ncbi.nlm.nih.gov
Bioinformatics Analysis of Differentially Expressed Genes and Protein–Protein Interaction
Networks Associated with Functional Pathways in Ulcerative Colitis - PMC Back to Top Skip to …

LncRNA-miRNA-mRNA network analysis reveals the potential biomarkers in Crohn's disease rats treated with herb-partitioned moxibustion

XJ Wang, XY Li, XC Guo, L Liu, YY Jin… - Journal of …, 2022 - Taylor & Francis
Background Long noncoding RNA (lncRNA) is receiving growing attention in Crohn's
disease (CD). However, the mechanism by which herb-partitioned moxibustion (HPM) …

[HTML][HTML] Identification of hub genes in rheumatoid arthritis through an integrated bioinformatics approach

R Wu, L Long, Q Zhou, J Su, W Su, J Zhu - Journal of orthopaedic surgery …, 2021 - Springer
Background Rheumatoid arthritis (RA) is a common chronic autoimmune disease
characterized by inflammation of the synovial membrane. However, the etiology and …

[HTML][HTML] Cytokine Signatures in Inflamed Mucosa of IBD Patients: State-of-the-Art

M Peruhova, D Miteva, M Kokudeva, S Banova… - Gastroenterology …, 2024 - mdpi.com
The process of development, recurrence, and exacerbation of the inflammatory process
depends on the cytokine levels in IBD. For that reason, many cytokine therapies have been …