Rhythmic increases in intracellular Ca2+ concentration underlie the contractile function of
the heart. These heart muscle-wide changes in intracellular Ca2+ are induced and …

Diabetic cardiomyopathy is defined as the myocardial dysfunction that suffers patients with
diabetes mellitus (DM) in the absence of hypertension and structural heart diseases such as …

This work evaluated the effects of long-term kefir treatment in cardiac function (cardiac
contractility and calcium-handling proteins) and the central nervous system (CNS) control of …

Heart failure (HF) manifestation and progression are driven by systemic activation of
neuroendocrine signaling cascades, such as the renin–angiotensin aldosterone system …

The initiation of a spatially and temporally limited inflammation is essential for tissue and
bone remodelling by the periodontal ligament (PdL) located between teeth and alveolar …

The contraction of cardiac muscle underlying the pumping action of the heart is mediated by
the process of excitation-contraction coupling (ECC). While triggered by Ca2+ entry across …

Heart failure (HF) with preserved ejection fraction (HFpEF) is present in about 50% of HF
patients. Atrial remodeling is common in HFpEF and associated with increased mortality. We …

The nucleus of a cardiomyocyte has been increasingly recognized as a morphologically
distinct and partially independent calcium (Ca2+) signaling microdomain, with its own Ca2+ …

Systemic arterial hypertension is a multifactorial clinical condition characterized by high and
sustained levels of blood pressure. For a better understanding of the pathophysiology of …

Aims Phospholamban (PLB) is the key regulator of the cardiac Ca 2+ pump (SERCA2a)-
mediated sarcoplasmic reticulum Ca 2+ stores. We recently reported that PLB is highly …