Despite vaccination programs, pertussis has been poorly controlled, especially among older
adults in Australia. This longitudinal, retrospective, observational study aimed to estimate the …

OBJECTIVE: To characterize Bordetella pertussis isolates in Ontario, Canada in order to
understand the clonal diversity of strains present in this province. METHODS: A total of 521 …

Background After the introduction of a vaccine against B. pertussis the seasonal pattern with
the highest number of infections in the spring to summer months changed. Recent studies …

Acellular pertussis vaccines combined with diphtheria and tetanus toxoids have proven to
be well tolerated, immunogenic and effective in reducing pertussis disease in adolescents …

Whooping cough caused by infection with Bordetella pertussis, is a serious illness in infants
and young children. Mortality due to whooping cough is being reported in infants too young …

There is increasing evidence and awareness that pertussis is not just a disease of children.
Although most severe disease and almost all mortality occur in young infants, the overall …

BACKGROUND: The incidence of pertussis in adults is high despite good childhood
vaccination coverage. An adult formulation of an acellular pertussis vaccine is licensed and …

Background: In Canada, the epidemiology of pertussis has changed during the past decade
such that more cases occur in adolescents than in any other age cohort. Methods: The …

Introduction Pertussis is a communicable disease that primarily affects infants. Vaccination
has led to an important reduction in the incidence of the disease, however, resurgence of the …

This review offers a perspective on the acellular pertussis vaccine efficiency trials concluded
in the 1990s and presents the main conclusions of a meta-analysis of 52 studies that …