Short-chain fatty acid: An updated review on signaling, metabolism, and therapeutic effects
K Rekha, B Venkidasamy, R Samynathan… - Critical Reviews in …, 2024 - Taylor & Francis
Fatty acids are good energy sources (9 kcal per gram) that aerobic tissues can use except
for the brain (glucose is an alternative source). Apart from the energy source, fatty acids are …
for the brain (glucose is an alternative source). Apart from the energy source, fatty acids are …
Revolutionizing drug development: harnessing the potential of organ-on-chip technology for disease modeling and drug discovery
N Sunildutt, P Parihar… - Frontiers in …, 2023 - frontiersin.org
The inefficiency of existing animal models to precisely predict human pharmacological
effects is the root reason for drug development failure. Microphysiological system/organ-on …
effects is the root reason for drug development failure. Microphysiological system/organ-on …
Carrier-free nanoparticles of camptothecin prodrug for chemo-photothermal therapy: The making, in vitro and in vivo testing
M Ao, F Yu, Y Li, M Zhong, Y Tang, H Yang… - Journal of …, 2021 - Springer
Background Nanoscale drug delivery systems have emerged as broadly applicable
approach for chemo-photothermal therapy. However, these nanoscale drug delivery …
approach for chemo-photothermal therapy. However, these nanoscale drug delivery …
An insight into the interaction between Indisulam and human serum albumin: Spectroscopic method, computer simulation and in vitro cytotoxicity assay
B Zhou, H Zhou, L Xu, R Cai, C Chen, B Chi, X Tuo - Bioorganic Chemistry, 2022 - Elsevier
Indisulam (IDM) is a sulfanilamide anticancer agent and has been identified as a molecular
glue recently. It shows potential for novel therapies development and brings more hope for …
glue recently. It shows potential for novel therapies development and brings more hope for …
Physicochemical and biopharmaceutical controllability of new self-assembled fatty acid conjugated leuprolide for the enhanced anticancer activity
HV Ngo, HE Bak, HD Nguyen, KW Lee… - International Journal …, 2023 - Taylor & Francis
Background Leuprolide (LEU), a synthetic nonapeptide analog of naturally occurring
gonadotropin-releasing hormone (GnRH), could exert a direct inhibitory activity on the …
gonadotropin-releasing hormone (GnRH), could exert a direct inhibitory activity on the …
Dietary fatty acid-mediated protein encapsulation simultaneously improving the water-solubility, storage stability, and oral absorption of astaxanthin
L Huang, D Li, Y Ma, Y Liu, G Liu, Y Wang, B Tan - Food Hydrocolloids, 2022 - Elsevier
A growing number of studies suggest that fatty acids (FAs) as ligands can improve protein's
affinity to hydrophobic small molecules. Therefore, this work investigated FA-mediated …
affinity to hydrophobic small molecules. Therefore, this work investigated FA-mediated …
Evaluation and live monitoring of pH-responsive HSA-ZnO nanoparticles using a lung-on-a-chip model
N Meghani, KH Kim, SH Kim, SH Lee… - Archives of Pharmacal …, 2020 - Springer
One of the key problems that have hindered the development and approval of anticancer
nanoparticle drug delivery systems is the limited predictability of 2D cell culture and animal …
nanoparticle drug delivery systems is the limited predictability of 2D cell culture and animal …
Cellular Efficacy of Fattigated Nanoparticles and Real-Time ROS Occurrence Using Microfluidic Hepatocarcinoma Chip System: Effect of Anticancer Drug Solubility …
The objective of this study was to evaluate the effectiveness of organ-on-chip system
investigating simultaneous cellular efficacy and real-time reactive oxygen species (ROS) …
investigating simultaneous cellular efficacy and real-time reactive oxygen species (ROS) …
Hydroxyl group-targeted conjugate and its self-assembled nanoparticle of peptide drug: Effect of degree of saturation of fatty acids and modification of …
J Park, HV Ngo, HE Jin, KW Lee… - International Journal of …, 2022 - Taylor & Francis
Purpose To conjugate different degree of saturation of C18 fatty acids (stearic acid, oleic
acid, and linoleic acid) with the hydroxyl groups of leuprolide acetate (LEU acetate) and to …
acid, and linoleic acid) with the hydroxyl groups of leuprolide acetate (LEU acetate) and to …
Utilization of a fattigation platform gelatin-oleic acid sodium salt conjugate as a novel solubilizing adjuvant for poorly water-soluble drugs via self-assembly and …
D Kim, C Park, NM Meghani, TTD Tran… - International journal of …, 2020 - Elsevier
Solubilizing adjuvants are commonly used to dissolve insoluble drugs by simply adding in a
formulation. In this study, gelatin and oleic acid sodium salt (OAS), a generally recognized …
formulation. In this study, gelatin and oleic acid sodium salt (OAS), a generally recognized …