In humans, the thyroid hormones T3 and T4 are synthesized in the thyroid gland in a
process that crucially involves the iodoglycoprotein thyroglobulin. The overall structure of …

Thyroglobulin (Tg) is a vertebrate secretory protein synthesized in the thyrocyte endoplasmic
reticulum (ER), where it acquires N-linked glycosylation and conformational maturation …

Thiol proteins may potentially act as redox signaling adaptor proteins, adjusting reactive
oxygen species intermediates to specific signals and redox signals to cell homeostasis. In …

Down syndrome (DS) is a genetic disorder caused by trisomy of chromosome 21.
Abnormalities in chromosome number have the potential to lead to disruption of the …

Primary congenital hypothyroidism (CH) is the most common endocrine disease in children
and one of the most common preventable causes of both cognitive and motor deficits. CH is …

Thyroglobulin (TG) defects due to TG gene mutations have an estimated incidence of
approximately 1 in 100,000 newborns. This dyshormonogenesis displays a wide phenotype …

Thyroglobulin (Tg) is a secreted iodoglycoprotein serving as the precursor for
triiodothyronine and thyroxine hormones. Many characterized Tg gene mutations produce …

In this paper, we report the high prevalence of thyroid malignancy in patients with
thyroglobulin mutations in Japan. Mutations of the thyroglobulin gene cause defective …

Thyroglobulin (TG) plays a main role in the biosynthesis of thyroid hormones (TH), and, thus,
it is involved in a wide range of vital functions throughout the life cycle of all vertebrates …

Human diseases caused by mutations in extracellular matrix genes are often associated
with an increased risk of cataract and lens capsular rupture. However, the underlying …