Cabozantinib, vandetanib, pralsetinib and selpercatinib as treatment for progressed medullary thyroid cancer with a main focus on hypertension as adverse effect

L Højer Wang, M Wehland, PM Wise… - International Journal of …, 2023 - mdpi.com
This manuscript investigates cabozantinib, vandetanib, pralsetinib, and selpercatinib, four
tyrosine kinase inhibitors (TKIs), which are used to treat advanced and/or metastatic …

Update on the diagnosis and management of medullary thyroid cancer: what has changed in recent years?

K Kaliszewski, M Ludwig, B Ludwig, A Mikuła… - Cancers, 2022 - mdpi.com
Simple Summary Medullary thyroid carcinoma (MTC) is a rare neoplasm that is responsible
for a fair proportion of thyroid carcinoma related deaths. The current diagnostic and …

State of the art in the current management and future directions of targeted therapy for differentiated thyroid cancer

H Silaghi, V Lozovanu, CE Georgescu, C Pop… - International Journal of …, 2022 - mdpi.com
Two-thirds of differentiated thyroid cancer (DTC) patients with distant metastases would be
classified as radioactive iodine-refractory (RAIR-DTC), evolving into a poor outcome. Recent …

[HTML][HTML] Molecular features of aggressive thyroid cancer

G Elia, A Patrizio, F Ragusa, SR Paparo… - Frontiers in …, 2022 - frontiersin.org
Poorly differentiated thyroid cancer (PDTC) and anaplastic thyroid cancer (ATC) have a
worse prognosis with respect to well differentiated TC, and the loss of the capability of up …

Drug-induced inhibition of HMGA and EZH2 activity as a possible therapy for anaplastic thyroid carcinoma

M De Martino, S Pellecchia, M Decaussin-Petrucci… - Cell Cycle, 2023 - Taylor & Francis
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal neoplasms in
humans, and just limited progresses have been made to extend patient survival and …

NTRK fusions in thyroid cancer: pathology and clinical aspects

Y Ma, Q Zhang, K Zhang, F Ren, J Zhang, C Kan… - Critical Reviews in …, 2023 - Elsevier
Thyroid cancer is the most common endocrine cancer. Neurotrophic tyrosine receptor kinase
(NTRK) fusions are oncogenic drivers in multiple solid tumors, including thyroid cancer …

Cyanidin as potential anticancer agent targeting various proliferative pathways

MA Safdar, RMN Aslam, A Shakeel… - Chemical Biology & …, 2023 - Wiley Online Library
A natural compound cyanidin, which is a type of anthocyanin present in pigmented leaves,
fruits, and flowers; distributed widely in berries, apples, and oranges possess anticancer …

Cancer gene analysis of liquid‐based cytology specimens using next‐generation sequencing: A technical report of bimodal DNA‐and RNA‐based panel application

T Akahane, T Isochi‐Yamaguchi… - Diagnostic …, 2023 - Wiley Online Library
Background As liquid‐based cytology (LBC) specimens harbor high‐quality DNA, genomic
analysis using LBC specimens is beneficial for integrative diagnosis. This study aimed to …

Rationale efficacy and safety evidence of Lenvatinib and Pembrolizumab Association in anaplastic thyroid carcinoma

L Boudin, JB Morvan, J Thariat, D Métivier, PY Marcy… - Current …, 2022 - mdpi.com
Anaplastic thyroid carcinoma (ATC) are highly aggressive malignant tumors with poor
overall prognosis despite multimodal therapy. As ATC are extremely rare, no randomized …

HLA-G Gene Variability Is Associated with Papillary Thyroid Carcinoma Morbidity and the HLA-G Protein Profile

BC Bertol, G Debortoli, FC Dias, JNG de Araújo… - International Journal of …, 2023 - mdpi.com
Human leukocyte antigen (HLA)-G is an immune checkpoint molecule that is highly
expressed in papillary thyroid carcinoma (PTC). The HLA-G gene presents several …