Cancer gene analysis of liquid‐based cytology specimens using next‐generation sequencing: a technical report of bimodal DNA‐and RNA‐based panel application

T Akahane, T Isochi‐Yamaguchi… - Diagnostic …, 2023 - Wiley Online Library
Background As liquid‐based cytology (LBC) specimens harbor high‐quality DNA, genomic
analysis using LBC specimens is beneficial for integrative diagnosis. This study aimed to …

[HTML][HTML] Clinicopathological and genetic characteristics of patients of different ages with diffuse sclerosing variant papillary thyroid carcinoma

SY Kim, SJ Shin, DG Lee, HJ Yun, SM Kim, H Chang… - Cancers, 2023 - mdpi.com
Simple Summary Diffuse sclerosing variant papillary thyroid carcinoma is a rare variant of
papillary thyroid carcinoma that is most frequently observed in young patients with different …

[HTML][HTML] Expression of pY397-FAK and Its miR Regulators Drive Dedifferentiation in the Thyroid Neoplasia Spectrum

V Ignjatović Jocić, J Janković Miljuš, T Išić Denčić… - Cells, 2023 - mdpi.com
Thyroid carcinomas are growing malignancies worldwide. They encompass several
diagnostic categories with varying degrees of dedifferentiation. Focal adhesion kinase is …

Drug-induced inhibition of HMGA and EZH2 activity as a possible therapy for anaplastic thyroid carcinoma

M De Martino, S Pellecchia, M Decaussin-Petrucci… - Cell Cycle, 2023 - Taylor & Francis
Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and lethal neoplasms in
humans, and just limited progresses have been made to extend patient survival and …

[HTML][HTML] Long-term survival outcomes of systemic therapy in patients with isolated and mixed medullary thyroid cancer

MS Fawzy, AA Alenezi, BTA AlSel, EA Toraih - Heliyon, 2024 - cell.com
Background Medullary thyroid carcinoma (MTC) is an uncommon thyroid cancer with limited
treatment options for advanced disease. A small subset exhibits mixed MTC histology with …

[HTML][HTML] Cancer Predisposition Syndromes and Thyroid Cancer: Keys for a Short Two-Way Street

I Balinisteanu, MC Panzaru, L Caba, MC Ungureanu… - Biomedicines, 2023 - mdpi.com
Cancer predisposition syndromes are entities determined especially by germinal pathogenic
variants, with most of them autosomal dominantly inherited. The risk of a form of cancer is …

Epidermal growth factor receptor activation confers resistance to lenvatinib in thyroid cancer cells

K Ohno, T Shibata, K Ito - Cancer Science, 2022 - Wiley Online Library
Thyroid cancer is the most common endocrine malignancy. A multitargeted tyrosine kinase
inhibitor, lenvatinib, has been used for the treatment of advanced thyroid cancer. To …

[HTML][HTML] Medullary Thyroid Cancer: Molecular Drivers and Immune Cellular Milieu of the Tumour Microenvironment—Implications for Systemic Treatment

AJ Papachristos, H Serrao-Brown, AJ Gill… - Cancers, 2024 - mdpi.com
Simple Summary Medullary thyroid carcinoma (MTC) is driven by a small number of
pathogenic genetic variants and tumours usually exhibit a correspondingly low tumour …

[HTML][HTML] The Incidence Trend and Management of Thyroid Cancer—What Has Changed in the Past Years: Own Experience and Literature Review

K Kaliszewski, D Diakowska, M Miciak, K Jurkiewicz… - Cancers, 2023 - mdpi.com
Simple Summary The incidence of thyroid cancer (TC) has increased greatly since the
1970s, mostly because of higher detection of the small forms of papillary thyroid cancer …

Advances in pharmacotherapy for advanced thyroid cancer of follicular origin (PTC, FTC). New approved drugs and future therapies

G Elia, SM Ferrari, F Ragusa, SR Paparo… - Expert Opinion on …, 2022 - Taylor & Francis
Introduction The most common altered signaling found in aggressive iodine-refractory
thyroid cancers derived from follicular cells (RAI-TC) are RTK, MAPK, PI3K, WNT, BRAF …