Lymphatic vessels, comprising the secondary circulatory system in human body, play a
multifaceted role in maintaining homeostasis among various tissues and organs. They are …

The ever-growing research on lymphatic biology has clearly identified lymphatic vessels as
key players that maintain human health through their functional roles in tissue fluid …

Lymphatic capillaries develop discontinuous cell-cell junctions that permit the absorption of
large macromolecules, chylomicrons, and fluid from the interstitium. While excessive …

Lymphedema and lipedema are complex diseases. While the external presentation of
swollen legs in lower-extremity lymphedema and lipedema appear similar, current …

Lymphedema is a progressive disease of the lymphatic system arising from impaired
lymphatic drainage, accumulation of interstitial fluid, and fibroadipose deposition. Secondary …

Obesity and metabolic syndrome pose a significant risk for developing cardiovascular
disease and remain a critical healthcare challenge. Given the lymphatic system's role as a …

The tumor microenvironment (TME) is an intricate complex and dynamic structure composed
of various cell types, including tumor, stromal and immune cells. Within this complex …

Resolution of edema remains a significant clinical challenge. Conditions such as traumatic
shock, sepsis, or diabetes often involve microvascular hyperpermeability, which leads to …

Background The lymphatic contribution to the circulation is of paramount importance in
regulating fluid homeostasis, immune cell trafficking/activation and lipid metabolism. In …

Secondary lymphedema often occurs after filariasis, trauma, lymph node dissection and
radiation therapy, which is manifested by infiltration of inflammatory cells and fibrosis …