The precise orchestration of hormonal regulation at all levels of the hypothalamic-pituitary-
gonadal axis is essential for normal reproductive function and fertility. The pulsatile secretion …

Reproduction and fertility are regulated via hormones of the hypothalamic‐pituitary‐gonadal
(HPG) axis. Control of this reproductive axis occurs at all levels, including the brain and …

The liver receptor homolog-1 (LRH-1; NR5A2) and steroidogenic factor-1 (SF-1; NR5A1) are
two orphan members of the Ftz-F1 subfamily of nuclear receptors. LRH-1 is expressed in …

Gonadotropin-releasing hormone (GnRH) is the first key hormone of reproduction. GnRH
analogs are extensively used in in vitro fertilization, and treatment of sex hormone …

The immediate-early gene product and zinc finger transcription factor early growth response
(Egr)-1 plays a key master regulatory role in multiple cardiovascular pathological processes …

The precise interplay of hormonal influences that governs gonadotropin hormone production
by the pituitary includes endocrine, paracrine and autocrine actions of hypothalamic …

Estrogens profoundly influence the physiology and pathology of reproductive and other
tissues. Consequently, emphasis has been placed on delineating the mechanisms …

The frequency of gonadotropin-releasing hormone (GNRH1, or GnRH) pulses secreted from
the hypothalamus determine the ratios of the gonadotropin subunit genes luteinizing …

BACKGROUND Menarche is the first menstrual period of a girl at puberty. The timing of
menarche is important for health in later life. Age at menarche is a complex trait and has a …

Mammalian reproduction is controlled by the hypothalamic-pituitary-gonadal axis. GnRH
from the hypothalamus regulates synthesis and secretion of gonadotropins, LH and FSH …