Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Data generated by genome-wide association studies (GWAS) are growing fast with the
linkage of biobank samples to health records, and expanding capture of high-dimensional …

Importance Growing evidence suggests that prescription opioid use affects depression and
anxiety disorders; however, observational studies are subject to confounding, making causal …

Drug development in cardiovascular disease is stagnating, with lack of efficacy and adverse
effects being barriers to innovation. Human genetics can provide compelling evidence of …

Randomized controlled trials and Mendelian randomization studies are two study designs
that provide randomized evidence in human biological and medical research. Both exploit …

Importance Psoriasis, psoriatic arthritis, and inflammatory bowel disease, ie, Crohn disease
and ulcerative colitis, are chronic systemic immune-mediated disorders affecting an …

Alcohol consumption has been shown to have complex, and sometimes paradoxical,
associations with cardiovascular diseases (CVDs). Several hundred epidemiological studies …

The rising prevalence of childhood obesity has been postulated as an explanation for the
increasing rate of individuals diagnosed with type 1 diabetes (T1D). In this study, we use …

This review discusses the inconsistent recommendations on alcohol consumption and its
association with chronic disease, highlighting the need for an evidence-based consensus …