Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …

Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …

Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …

Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

Chondrocytes are responsible for the maintenance of the articular cartilage. A loss of
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …

There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …

Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …

This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …

Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …

Senescence or normal physiologic aging portrays the expected age-related changes in the
kidney as compared to a disease that occurs in some but not all individuals. The …