ROS: basic concepts, sources, cellular signaling, and its implications in aging pathways
AJPO de Almeida, JCPL de Oliveira… - Oxidative medicine …, 2022 - Wiley Online Library
Reactive oxygen species (ROS) are bioproducts of cellular metabolism. There is a range of
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
molecules with oxidizing properties known as ROS. Despite those molecules being implied …
[HTML][HTML] Antioxidant and oxidative stress: a mutual interplay in age-related diseases
Aging is the progressive loss of organ and tissue function over time. Growing older is
positively linked to cognitive and biological degeneration such as physical frailty …
positively linked to cognitive and biological degeneration such as physical frailty …
Vascular inflammation and oxidative stress: major triggers for cardiovascular disease
S Steven, K Frenis, M Oelze, S Kalinovic… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular disease is a leading cause of death and reduced quality of life, proven by
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …
the latest data of the Global Burden of Disease Study, and is only gaining in prevalence …
Evolution of the knowledge of free radicals and other oxidants
S Di Meo, P Venditti - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …
unpaired electrons in their external orbitals and generally display a remarkable reactivity …
Reactive oxygen species, aging and articular cartilage homeostasis
JA Bolduc, JA Collins, RF Loeser - Free Radical Biology and Medicine, 2019 - Elsevier
Chondrocytes are responsible for the maintenance of the articular cartilage. A loss of
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …
homeostasis in cartilage contributes to the development of osteoarthritis (OA) when the …
Role of ROS and RNS sources in physiological and pathological conditions
S Di Meo, TT Reed, P Venditti… - Oxidative medicine and …, 2016 - Wiley Online Library
There is significant evidence that, in living systems, free radicals and other reactive oxygen
and nitrogen species play a double role, because they can cause oxidative damage and …
and nitrogen species play a double role, because they can cause oxidative damage and …
Ageing and the pathogenesis of osteoarthritis
RF Loeser, JA Collins, BO Diekman - Nature Reviews Rheumatology, 2016 - nature.com
Ageing-associated changes that affect articular tissues promote the development of
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …
osteoarthritis (OA). Although ageing and OA are closely linked, they are independent …
Mitochondrial generation of superoxide and hydrogen peroxide as the source of mitochondrial redox signaling
MD Brand - Free Radical Biology and Medicine, 2016 - Elsevier
This review examines the generation of reactive oxygen species by mammalian
mitochondria, and the status of different sites of production in redox signaling and pathology …
mitochondria, and the status of different sites of production in redox signaling and pathology …
[HTML][HTML] Mitochondrial dysfunction in metabolic syndrome
P Prasun - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2020 - Elsevier
Metabolic syndrome is co-occurrence of obesity, insulin resistance, atherogenic
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …
dyslipidemia (high triglyceride, low high density lipoprotein cholesterol), and hypertension. It …
Structural and functional changes with the aging kidney
Senescence or normal physiologic aging portrays the expected age-related changes in the
kidney as compared to a disease that occurs in some but not all individuals. The …
kidney as compared to a disease that occurs in some but not all individuals. The …