Lysosomal dysfunction in neurodegeneration: emerging concepts and methods
V Udayar, Y Chen, E Sidransky, R Jagasia - Trends in neurosciences, 2022 - cell.com
The understanding of lysosomes has come a long way since the initial discovery of their role
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …
in degrading cellular waste. The lysosome is now recognized as a highly dynamic organelle …
[HTML][HTML] Impairment of the autophagy–lysosomal pathway in Alzheimer's diseases: pathogenic mechanisms and therapeutic potential
Abstract Alzheimer's disease (AD), the most common neurodegenerative disorder, is
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
characterized by memory loss and cognitive dysfunction. The accumulation of misfolded …
STING trafficking as a new dimension of immune signaling
D Jeltema, K Abbott, N Yan - Journal of Experimental Medicine, 2023 - rupress.org
The cGAS–STING pathway is an evolutionarily conserved immune signaling pathway critical
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …
for microbial defense. Unlike other innate immune pathways that largely rely on stationary …
Defective lysosomal acidification: a new prognostic marker and therapeutic target for neurodegenerative diseases
Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …
[HTML][HTML] The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via …
ER Gallagher, ELF Holzbaur - Cell reports, 2023 - cell.com
In response to lysosomal damage, cells engage several quality-control mechanisms,
including the selective isolation and degradation of damaged lysosomes by lysophagy …
including the selective isolation and degradation of damaged lysosomes by lysophagy …
Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency
A Reifschneider, S Robinson, B van Lengerich… - The EMBO …, 2022 - embopress.org
Haploinsufficiency of the progranulin (PGRN)‐encoding gene (GRN) causes frontotemporal
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …
lobar degeneration (GRN‐FTLD) and results in microglial hyperactivation, TREM2 …
Comprehensive research on past and future therapeutic strategies devoted to treatment of amyotrophic lateral sclerosis
Amyotrophic lateral sclerosis (ALS) is a rapidly debilitating fatal neurodegenerative disorder,
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
causing muscle atrophy and weakness, which leads to paralysis and eventual death. ALS …
[HTML][HTML] Fluorescent probes for imaging bioactive species in subcellular organelles
SK Pramanik, A Das - Chemical Communications, 2021 - pubs.rsc.org
Luminescent molecular probes and nanoscale materials have become important tools in
biosensing and bioimaging applications because of their high sensitivity, fast response …
biosensing and bioimaging applications because of their high sensitivity, fast response …
Overlapping neuroimmune mechanisms and therapeutic targets in neurodegenerative disorders
Many potential immune therapeutic targets are similarly affected in adult-onset
neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD) …
neurodegenerative diseases, such as Alzheimer's (AD) disease, Parkinson's disease (PD) …
Neuronal ceroid lipofuscinosis: the multifaceted approach to the clinical issues, an overview
A Simonati, RE Williams - Frontiers in neurology, 2022 - frontiersin.org
The main aim of this review is to summarize the current state-of-art in the field of childhood
Neuronal Ceroid Lipofuscinosis (NCL), a group of rare neurodegenerative disorders. These …
Neuronal Ceroid Lipofuscinosis (NCL), a group of rare neurodegenerative disorders. These …