Introduction Synaptic degeneration is a key part of the pathophysiology of
neurodegenerative diseases, and biomarkers reflecting the pathological alterations are …

Background Genome-wide association studies (GWAS) have indicated moderate genetic
overlap between Alzheimer's disease (AD) and related dementias (ADRD), Parkinson's …

Since the initial identification of TMEM106B as a risk factor for frontotemporal lobar
degeneration (FTLD), multiple genetic studies have found TMEM106B variants to modulate …

Background Autosomal dominant mutations in α-synuclein, TDP-43 and tau are thought to
predispose to neurodegeneration by enhancing protein aggregation. While a subset of α …

Abstract Background Motor neurons (MNs), which are primarily affected in amyotrophic
lateral sclerosis (ALS), are a specialized type of neurons that are long and non-dividing …

GGC repeat expansions within NOTCH2NLC have been identified as the genetic cause of
neuronal intranuclear inclusion disease (NIID). To understand the molecular pathogenesis …

Neoadjuvant and adjuvant therapies have made significant progress in cancer treatment.
However, tumor adjuvant therapy still faces challenges due to the intrinsic heterogeneity of …

Silver nanoparticles have many medical and commercial applications, but their effects on
human health are poorly understood. They are used extensively in products of daily use, but …

Proteinopathy and neuroinflammation are two main hallmarks of neurodegenerative
diseases. They also represent rare common events in an exceptionally broad landscape of …

Aging is associated with loss of circadian immune responses and circadian gene
transcription in peripheral macrophages. Microglia, the resident macrophages of the brain …