Over the past two decades, increased research has highlighted the connection between
endosomal trafficking defects and neurodegeneration. The endo-lysosomal network is an …

The cytoplasmic accumulation of the nuclear protein transactive response DNA-binding
protein 43 kDa (TDP-43) has been linked to the progression of amyotrophic lateral sclerosis …

Although microglial activation is induced by an increase in chemokines, the role of
mitophagy in this process remains unclear. This study aimed to elucidate the role of …

Frontotemporal dementia (FTD) is the second most common form of dementia. It affects the
frontal and temporal lobes of the brain and has a highly heterogeneous clinical …

Background Progranulin (PGRN) is a lysosomal glycoprotein implicated in various
neurodegenerative diseases, including frontotemporal dementia and neuronal ceroid …

Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale
organization of proteins, RNAs, and membrane-bound organelles into biomolecular …

Neurodegenerative proteinopathies are defined as a class of neurodegenerative disorders,
with either genetic or sporadic age‐related onset, characterized by the pathological …

Proteinopathies are a large group of neurodegenerative diseases caused by both genetic
and sporadic mutations in particular genes which can lead to alterations of the protein …

Neurodegenerative diseases (NDs) constitute a group of disorders characterized by the
progressive deterioration of nervous system functionality. Currently, the precise etiological …

Multiple complex intracellular cascades contributing to Hunter syndrome (
mucopolysaccharidosis type II) pathogenesis have been recognized and documented in the …