The pathophysiology of ALS involves many signs of a disruption in copper homeostasis, with
both excess free levels and functional deficiency likely occurring simultaneously. This is …

Abstract Alzheimer's disease (AD), the most common aging-associated neurodegenerative
dementia disorder, is defined by the presence of amyloid beta (Aβ) and tau aggregates in …

Neurons are post-mitotic cells that allocate huge amounts of energy to the synthesis of new
organelles and molecules, neurotransmission and to the maintenance of redox …

Heterozygous loss-of-function mutations in the GRN gene are a major cause of hereditary
frontotemporal dementia. The mechanisms linking frontotemporal dementia pathogenesis to …

Frontotemporal lobar degeneration (FTLD) is a neurodegenerative disorder clinically
characterized by behavioral, language, and motor symptoms, with major impact on the lives …

Amyotrophic lateral sclerosis (ALS) is the most common neurodegenerative disorder of
motor neurons in adults, with a median survival of 3–5 years after appearance of symptoms …

Cytoplasmic inclusions containing aberrant proteolytic fragments of TDP-43 are associated
with frontotemporal lobar degeneration (FTLD) and other related pathologies. In FTLD, TDP …

Millions of people are suffering from Alzheimer's disease globally, but there is still no
effective treatment for this neurodegenerative disease. Thus, novel therapeutic approaches …

As a self‐degrading and highly conserved survival mechanism, autophagy plays an
important role in maintaining cell survival and recycling. The discovery of autophagy‐related …

Abstract A GGGGCC (G4C2) repeat expansion in the C9orf72 gene is the most common
genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) …