Frontotemporal dementia (FTD) is the second most prevalent type of early-onset dementia
and up to 40% of cases are familial forms. One of the genes mutated in patients is CHMP2B …

Loss of function progranulin (GRN) mutations are a major autosomal dominant cause of
frontotemporal dementia (FTD). Patients with FTD due to GRN mutations (FTD-GRN) …

Progranulin (PGRN) deficiency is linked to neurodegenerative diseases including
frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and neuronal ceroid …

Amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) lie at
opposing ends of a clinical, genetic, and neuropathological continuum. In the last decade, it …

In this review, we shed light on recent advances regarding the characterization of
biochemical pathways of cellular mechanosensing and mechanotransduction with particular …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
motor neuron loss accompanied by cytoplasmic localization of TDP-43 proteins and their …

Frontotemporal dementia and/or amyotrophic lateral sclerosis type 7 (FTD/ALS7) is an
autosomal dominant neurodegenerative disorder characterized by the onset of FTD and/or …

Genome-wide association studies identified a role for TMEM106B in various
neurodegenerative diseases. Based on long-read whole-genome sequencing data of 256 …

Unbiased data-driven omic approaches are revealing the molecular heterogeneity of
Alzheimer disease. Here, we used machine learning approaches to integrate high …

Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral
sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic …