Iron is an essential nutrient that facilitates cell proliferation and growth. However, iron also
has the capacity to engage in redox cycling and free radical formation. Therefore, iron can …

Ferroptosis is a recently discovered distinct type of regulated cell death caused by the
accumulation of lipid-based ROS. Metabolism and expression of specific genes affect the …

Recently lots of efforts have been taken to develop superparamagnetic iron oxide
nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in …

Superparamagnetic iron oxide nanoparticles (SPION) are being widely used for various
biomedical applications, for example, magnetic resonance imaging, targeted delivery of …

New therapeutic strategies have emerged along with our understanding that disturbances of
iron homeostasis, impaired proliferation of erythroid progenitor cells, and blunted …

We screened small molecules to identify two compounds, which we named RSL3 and RSL5,
that have increased lethality in the presence of oncogenic RAS. Counter screening with …

With the rapid expansion in the nanotechnology industry, it is essential that the safety of
engineered nanomaterials and the factors that influence their associated hazards are …

It is increasingly proposed that reactive oxygen species (ROS) and reactive nitrogen species
(RNS) play a key role in human cancer development [1–6], especially as evidence is …

Context.—A large number of epidemiologic studies have reported on associations between
various" inflammatory" factors and coronary heart disease (CHD). Objective.—To assess the …

Iron has been suggested as a risk factor for different types of cancers mainly due to its
prooxidant activity, which can lead to oxidative DNA damage. Furthermore, subjects with …