A high-intensity potentially tissue-injuring stimulus generates a homotopic response to
escape the stimulus and is associated with an affective phenotype considered to represent …

Neuroplastic changes in the neuronal networks involving the trigeminal ganglion (TG),
trigeminal spinal subnucleus caudalis (Vc), and upper cervical spinal cord (C1/C2) are …

Background Neuroinflammation plays a vital role in the development and maintenance of
neuropathic pain. Recent evidence has proved that bone marrow mesenchymal stem cells …

Neuron-glia interactions contribute to pain initiation and sustainment. Intra-ganglionic (IG)
secretion of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) …

Orofacial pain is a universal predicament, afflicting millions of individuals worldwide.
Research on the molecular mechanisms of orofacial pain has predominately focused on the …

There is increasing evidence of sex differences in underlying mechanisms causing pain in
preclinical models, and in clinical populations. There are also important disconnects …

Cocaine use disorder is a major health crisis that is associated with increased oxidative
stress and neuroinflammation. While the role of NLRP3 inflammasome in mediating …

The voltage-gated sodium channel subtype Nav1. 6 is involved in the electrophysiological
changes of primary sensory neurons that occur in oxaliplatin-induced neuropathic pain, but …

Neuropathic pain is a debilitating chronic pain condition and is refractory to the currently
available treatments. Emerging evidence suggests that melatonin exerts analgesic effects in …

Calcitonin gene-related peptide (CGRP) plays a crucial role in the modulation of orofacial
pain, and we hypothesized that CGRP mediated a neuron-glia crosstalk in orofacial pain …