There is an urgent clinical need for an appropriate method to shorten skin healing time.
Among most factors related to wound healing, M2 macrophages will be recruited to the …

Experimental models for chronic skin lesions are excision and pressure ulcer, defined as
“open” and “closed” lesions, respectively, only the latter characterized by tissue hypoxia …

The forkhead box O (FOXO) family has been extensively investigated in aging and
metabolism, but its role in tissue-repair processes remains largely unknown. Herein, we …

Calpains are a family of calcium-dependent non-lysosomal cysteine proteases. In particular,
calpains residing in the endothelial cells play important roles in angiogenesis. It has been …

Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible
remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase …

Renal microvascular (MV) damage and loss contribute to the progression of renal injury in
renovascular disease (RVD). Whether a targeted intervention in renal microcirculation could …

Abnormal angiogenesis plays an important role in impaired wound healing and
development of chronic wounds in diabetes mellitus. Angelica dahurica radix is a common …

Arterial morphogenesis is one of the most critical events during embryonic vascular
development. Although arterial fate specification is mainly controlled by the Notch signaling …

Injury-and ischemia-induced angiogenesis is critical for tissue repair and requires nitric
oxide (NO) derived from endothelial nitric oxide synthase (eNOS). We present evidence that …

The formation of endothelial lumen is fundamental to angiogenesis and essential to the
oxygenation of hypoxic tissues. The molecular mechanism underlying this important process …