The need for innovative anticancer treatments with high effectiveness and low toxicity is
urgent due to the development of malignancies that are resistant to chemotherapeutic …

Ethnopharmacological relevance Licorice has been commonly used in traditional Chinese
medicine for treatment of gastric, liver, and respiratory disease conditions for more than two …

Simple Summary Isoliquiritigenin (ISL), a natural bioactive compound with a chalcone
structure, demonstrates high antitumor efficacy. This review presents a summary of the latest …

Hypoxia, a condition of low oxygen availability, is a hallmark of tumour microenvironment
and promotes cancer progression and resistance to therapy. Many studies reported the …

Osteoarthritis (OA) is a common degenerative disease of the joints. It is primarily caused by
age, obesity, mechanical damage, genetics, and other factors, leading to cartilage …

There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Simple Summary Despite the important progress in cancer treatment in the past decades,
the mortality rates in some types of cancer have not significantly decreased. Therefore, the …

Glycyrrhizae Radix et Rhizoma is the most frequently prescribed natural medicine in China
and has been used for more than 2,000 years. The flavonoids of licorice have garnered …

Licorice flavonoids (LCFs) are natural flavonoids isolated from Glycyrrhiza which are known
to have anti-melanoma activities in vitro. However, the molecular mechanism of LCF anti …

Background Isoliquiritigenin (ISL), a natural flavonoid isolated from the root of licorice
(Glycyrrhiza uralensis), has shown various pharmacological properties including anti …