[HTML][HTML] Antiproliferative and palliative activity of flavonoids in colorectal cancer

J Fernandez, B Silván, R Entrialgo-Cadierno… - Biomedicine & …, 2021 - Elsevier
Flavonoids are plant bioactive compounds of great interest in nutrition and pharmacology,
due to their remarkable properties as antioxidant, anti-inflammatory, antibacterial, antifungal …

Neuropathic pain: from mechanisms to treatment

NB Finnerup, R Kuner, TS Jensen - Physiological reviews, 2021 - journals.physiology.org
Neuropathic pain caused by a lesion or disease of the somatosensory nervous system is a
common chronic pain condition with major impact on quality of life. Examples include …

Pain-resolving immune mechanisms in neuropathic pain

NT Fiore, SR Debs, JP Hayes, SS Duffy… - Nature Reviews …, 2023 - nature.com
Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

[HTML][HTML] Challenges of neuropathic pain: focus on diabetic neuropathy

DC Rosenberger, V Blechschmidt… - Journal of Neural …, 2020 - Springer
Neuropathic pain is a frequent condition caused by a lesion or disease of the central or
peripheral somatosensory nervous system. A frequent cause of peripheral neuropathic pain …

Animal models of chronic pain: advances and challenges for clinical translation

NE Burma, H Leduc‐Pessah, CY Fan… - Journal of …, 2017 - Wiley Online Library
Chronic pain is a global problem that has reached epidemic proportions. An estimated 20%
of adults suffer from pain, and another 10% are diagnosed with chronic pain each year …

A critical review of neurobiological factors involved in the interactions between chronic pain, depression, and sleep disruption

PA Boakye, C Olechowski, S Rashiq… - The Clinical Journal …, 2016 - journals.lww.com
Aims/Objectives/Background: A significant number of people who experience chronic pain
also complain of depression and sleep problems. The comorbidities and bidirectional …

[HTML][HTML] Behavioral, biochemical and electrophysiological changes in spared nerve injury model of neuropathic pain

F Guida, D De Gregorio, E Palazzo, F Ricciardi… - International journal of …, 2020 - mdpi.com
Neuropathic pain is a pathological condition induced by a lesion or disease affecting the
somatosensory system, with symptoms like allodynia and hyperalgesia. It has a multifaceted …

The sciatic nerve injury model in pre-clinical research

S Geuna - Journal of neuroscience methods, 2015 - Elsevier
In the pre-clinical view, the study of peripheral nerve repair and regeneration still needs to
be carried out in animal models due to the structural complexity of this organ which can be …

[HTML][HTML] The genetics of neuropathic pain from model organisms to clinical application

M Calvo, AJ Davies, HL Hebert, GA Weir, EJ Chesler… - Neuron, 2019 - cell.com
Neuropathic pain (NeuP) arises due to injury of the somatosensory nervous system and is
both common and disabling, rendering an urgent need for non-addictive, effective new …

Glial and neuroimmune cell choreography in sexually dimorphic pain signaling

É Midavaine, J Côté, S Marchand, P Sarret - Neuroscience & Biobehavioral …, 2021 - Elsevier
Chronic pain is a major global health issue that affects all populations regardless of sex,
age, ethnicity/race, or country of origin, leading to persistent physical and emotional distress …