Targeting NEK2 as a promising therapeutic approach for cancer treatment
Y Fang, X Zhang - Cell Cycle, 2016 - Taylor & Francis
ABSTRACT Never in Mitosis (NIMA) Related Kinase 2 (NEK2) plays a key role in regulating
mitotic processes, including centrosome duplication and separation, microtubule …
mitotic processes, including centrosome duplication and separation, microtubule …
[HTML][HTML] The role of ARF family proteins and their regulators and effectors in cancer progression: a therapeutic perspective
The Adenosine diphosphate-Ribosylation Factor (ARF) family belongs to the RAS
superfamily of small GTPases and is involved in a wide variety of physiological processes …
superfamily of small GTPases and is involved in a wide variety of physiological processes …
[HTML][HTML] Stemness related genes revealed by network analysis associated with tumor immune microenvironment and the clinical outcome in lung adenocarcinoma
H Zeng, J Ji, X Song, Y Huang, H Li, J Huang… - Frontiers in …, 2020 - frontiersin.org
Lung adenocarcinoma (LUAD) is one of the leading fatal malignancy with high morbidity
and mortality worldwide. However, due to its complicated mechanism and lack of effective …
and mortality worldwide. However, due to its complicated mechanism and lack of effective …
[HTML][HTML] KIF15 promotes pancreatic cancer proliferation via the MEK–ERK signalling pathway
J Wang, X Guo, C Xie, J Jiang - British journal of cancer, 2017 - nature.com
Background: Pancreatic cancer is highly malignant and characterised by rapid and
uncontrolled growth. While some of the important regulatory networks involved in pancreatic …
uncontrolled growth. While some of the important regulatory networks involved in pancreatic …
Increased accuracy of genomic predictions for growth under chronic thermal stress in rainbow trout by prioritizing variants from GWAS using imputed sequence data
GM Yoshida, JM Yáñez - Evolutionary applications, 2022 - Wiley Online Library
Through imputation of genotypes, genome‐wide association study (GWAS) and genomic
prediction (GP) using whole‐genome sequencing (WGS) data are cost‐efficient and feasible …
prediction (GP) using whole‐genome sequencing (WGS) data are cost‐efficient and feasible …
[HTML][HTML] The importance of CDC27 in cancer: molecular pathology and clinical aspects
GE Kazemi-Sefat, M Keramatipour, S Talebi… - Cancer cell …, 2021 - Springer
Background CDC27 is one of the core components of Anaphase Promoting
complex/cyclosome. The main role of this protein is defined at cellular division to control cell …
complex/cyclosome. The main role of this protein is defined at cellular division to control cell …
Arf proteins in cancer cell migration
Members of the ADP-ribosylation factor (Arf) family of small GTP-binding (G) proteins
regulate several aspects of membrane trafficking, such as vesicle budding, tethering and …
regulate several aspects of membrane trafficking, such as vesicle budding, tethering and …
[HTML][HTML] Genome-scale analysis identifies NEK2, DLGAP5 and ECT2 as promising diagnostic and prognostic biomarkers in human lung cancer
YX Shi, JY Yin, Y Shen, W Zhang, HH Zhou, ZQ Liu - Scientific reports, 2017 - nature.com
This study aims to identify promising biomarkers for the early detection of lung cancer and
evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data …
evaluate the prognosis of lung cancer patients. Genome-wide mRNA expression data …
[HTML][HTML] Analysis of genomic and transcriptomic variations as prognostic signature for lung adenocarcinoma
T Zengin, T Önal-Süzek - BMC bioinformatics, 2020 - Springer
Background Lung cancer is the leading cause of the largest number of deaths worldwide
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …
and lung adenocarcinoma is the most common form of lung cancer. In order to understand …
NUSAP1 knockdown inhibits cell growth and metastasis of non‐small‐cell lung cancer through regulating BTG2/PI3K/Akt signaling
ZY Xu, Y Wang, J Xiong, FX Cui… - Journal of Cellular …, 2020 - Wiley Online Library
Non‐small‐cell lung cancer (NSCLC) is the most common malignancy along with high
mortality rate worldwide. Recently, nucleolar and spindle‐associated protein 1 (NUSAP1) …
mortality rate worldwide. Recently, nucleolar and spindle‐associated protein 1 (NUSAP1) …