Advances in neuroscience identified addiction as a chronic brain disease with strong
genetic, neurodevelopmental, and sociocultural components. We here discuss the circuit …

Early adolescent substance use dramatically increases the risk of lifelong substance use
disorder (SUD). An adolescent sensitive period evolved to allow the development of risk …

BACKGROUND: Despite efforts to reduce nonmedical opioid misuse, little is known about
the development of persistent opioid use after surgery among adolescents and young …

Results. There were 79.5 million prescriptions for opioid analgesics captured (39% of the
estimated projection of 201.9 million opioid prescriptions dispensed in the US in 2009). Most …

Substance use disorders (SUDs), defined as a collection of symptoms including tolerance
and withdrawal, are chronic illnesses characterized by relapse and remission. In the United …

Substance use disorders (SUDs) manifest as chronic relapsing disorders, characterized by
compulsive drug taking despite serious adverse consequences, the loss of control over …

Adolescence is a period of increased behavioral and psychiatric vulnerabilities. It is also a
time of dramatic structural and functional neurodevelopment. In recent years studies have …

In the past 5 years, the use of nicotine delivered through electronic cigarettes (“e-cigarettes”)
has sky-rocketed among adolescents and young adults. E-cigarettes, with their high nicotine …

Cigarette smoking is often initiated during adolescence and an earlier age of onset is
associated with worse health outcomes later in life. Paradoxically, the transition towards …

Postnatal brain development is studded with sensitive periods during which experience
dependent plasticity is enhanced. This enables rapid learning from environmental inputs …