Transcription factors play an indispensable role in maintaining cellular viability and finely
regulating complex internal metabolic networks. These crucial bioactive functions rely on …

As a promising industrial microorganism, methylotroph is capable of using methane or
methanol as the sole carbon source natively, which has been utilized in the biosynthesis of …

Serratia marcescens, a Gram-negative bacterium, is one of the known disease-causing
pathogens. It is resistant to ampicillin, macrolides, cephalosporins, cefotaxime, and …

BarA/UvrY, a two-component system and global regulator that controls expression of more
than a hundred of genes involved in virulence, motility, biofilm formation, and central carbon …

Tolerance to acid stress is a crucial property of probiotics against gastric acids. The
malolactic enzyme pathway is one of the most important acid resistance systems in lactic …

Simple Summary With the advancement of synthetic biology and metabolic engineering,
regulatory elements applied for the accurate expression of target genes have become more …

Acidithiobacillus caldus is a typical extreme acidophile widely used in the
biohydrometallurgical industry, which often experiences extreme environmental stress in its …

Corynebacterium glutamicum plays a crucial role as a significant industrial producer of
metabolites. Despite the successful development of CRISPR-Cas9 and CRISPR-Cas12a …

Prodigiosin (PG) is a red tripyrrole pigment from the prodiginine family that has attracted
widespread attention due to its excellent biological activities, including anticancer …

Abstract Background (R)-mandelic acid (R-MA) is a highly valuable hydroxyl acid in the
pharmaceutical industry. However, biosynthesis of optically pure R-MA remains significant …