Abstract Phosphoinositide 3-kinases (PI3Ks) function early in intracellular signal
transduction pathways and affect many biological functions. A further level of complexity …

Cellular organelles in the exocytic and endocytic pathways have a distinctive spatial
distribution and communicate through an elaborate system of vesiculo-tubular transport …

3-Methyladenine which stops macroautophagy at the sequestration step in mammalian cells
also inhibits the phosphoinositide 3-kinase (PI3K) activity raising the possibility that PI3K …

Rab proteins constitute the largest branch of the Ras GTPase superfamily. Rabs use the
guanine nucleotide-dependent switch mechanism common to the superfamily to regulate …

Tuma, Pamela L., and Ann L. Hubbard. Transcytosis: Crossing Cellular Barriers. Physiol Rev
83: 871–932, 2003; 10.1152/physrev. 00001.2003.—Transcytosis, the vesicular transport of …

The Class III PI3K (phosphoinositide 3-kinase), Vps34 (vacuolar protein sorting 34), was first
described as a component of the vacuolar sorting system in Saccharomyces cerevisiae and …

Summary Phosphatidylinositol 3-phosphate (PI (3) P), the product of class III PI3K VPS34,
recruits specific autophagic effectors, like WIPI2, during the initial steps of autophagosome …

Autophagy is best known for its role in organelle and protein turnover, cell quality control,
and metabolism. The autophagic machinery has, however, also adapted to enable protein …

Live Mycobacterium tuberculosis persists in macrophage phagosomes by interfering with
phagolysosome biogenesis. Here, using four-dimensional microscopy and in vitro assays …

Many signaling pathways converge on and regulate phosphoinositide 3-kinase (PI3K)
enzymes whose inositol lipid products are key mediators of intracellular signaling. Different …