The evolutionally conserved DNA damage response (DDR) and cell cycle checkpoints
preserve genome integrity. Central to these genome surveillance pathways is a protein …

The DNA-damage response (DDR) pathways consist of interconnected components that
respond to DNA damage to allow repair and promote cell survival. The DNA repair pathways …

The current outbreak of Zika virus-associated diseases in South America and its threat to
spread to other parts of the world has emerged as a global health emergency. A strong link …

Drug combination therapies are commonly used for the treatment of cancers to increase
therapeutic efficacy, reduce toxicity, and decrease the incidence of drug resistance …

Venetoclax plus cytarabine therapy is approved for elderly acute myeloid leukemia (AML)
patients and needs further improvement. We studied the mechanisms of venetoclax plus …

Polyamines have received a lot of attention since the 1990s because of their anti‐aging, anti‐
chronic disease, and proliferative effects. Wheat germ was reported as one of the natural …

CHK1 regulates the DNA damage-induced checkpoint involving an ATR-or ATM-dependent
pathway. In this paper, we focused on the autophosphorylation of Ser296, one of the DNA …

OBJECTIVE: This study aimed to clarify the effects of zoledronic acid (ZOL) on human
primary oral mucosal keratinocytes growing in a monolayer culture and on a tissue …

The Chk1 kinase is highly conserved from yeast to humans and is well known to function in
the cell cycle checkpoint induced by genotoxic or replication stress. The activation of Chk1 is …

Plant ferredoxin‐like protein (PFLP) is a photosynthesis‐type ferredoxin (Fd) found in sweet
pepper. It contains an iron–sulphur cluster that receives and delivers electrons between …