Promoter-proximal pausing of RNA polymerase II (Pol II) is a key regulatory step during
transcription. Despite the central role of pausing in gene regulation, we do not understand …

Efficient co-transcriptional splicing is thought to suppress the formation of genome-
destabilizing R-loops upon interaction between nascent RNA and the DNA template …

Mouse embryonic stem cells (mESCs) can adopt naïve, ground, and paused pluripotent
states that give rise to unique transcriptomes. Here, we use transient transcriptome …

A large body of work in the last four decades has revealed the key pillars of HIV-1
transcription control at the initiation and elongation steps. Here, I provide a recount of this …

An important mediator of inflammation is prostaglandin E2 (PGE2), whose levels are
determined by the activity of the enzyme cyclooxygenase (COX). Of the two isoforms of the …

How DNA sequence affects the dynamics and position of RNA Polymerase II (Pol II) during
transcription remains poorly understood. Here, we used naturally occurring genetic variation …

Nucleolar ribosomal DNA (rDNA) repeats control ribosome manufacturing. rDNA harbors a
ribosomal RNA (rRNA) gene and an intergenic spacer (IGS). RNA polymerase (Pol) I …

Alu elements are one of the most successful groups of RNA retrotransposons and make up
11% of the human genome with over 1 million individual loci. They are linked to genetic …

RNA polymerase (Pol) II is highly regulated to ensure appropriate gene expression. Early
transcription elongation is associated with transient pausing of RNA Pol II in the promoter …

HIV-1 latency is a major barrier to curing infections with antiretroviral therapy and,
consequently, to eliminating the disease globally. The establishment, maintenance, and …