During eukaryotic transcription, RNA polymerases must initiate and pause within a crowded,
complex environment, surrounded by nucleosomes and other transcriptional activity. This …

Simple Summary Clock proteins and their collaborating transcription factors often act as
distal enhancers to regulate the rhythmic transcription of gene promoters. Those …

The modulation of GLI2, an oncogenic transcription factor commonly upregulated in cancer,
is in many cases not due to genetic defects, suggesting dysregulation through alternative …

Abstract Promoter-proximal Polymerase II (Pol II) pausing is a key rate-limiting step for gene
expression. DNA and RNA-binding trans-acting factors regulating the extent of pausing have …

The Elongin complex was originally identified as an RNA polymerase II (RNAPII) elongation
factor and subsequently as the substrate recognition component of a Cullin-RING E3 …

Across all branches of life, transcription elongation is a crucial, regulated phase in gene
expression. Many recent studies in eukaryotes have focused on the regulation of promoter …

Signal-induced transcriptional programs regulate critical biological processes through the
precise spatiotemporal activation of Immediate Early Genes (IEGs); however, the …

The mammalian FACT complex is a highly conserved histone chaperone with essential
roles in transcription elongation, histone deposition, and maintenance of stem cell state …

The role of histone modifications in transcription remains incompletely understood. Here we
used experimental perturbations combined with sensitive machine learning tools that infer …

Despite extensive characterization of mammalian Pol II transcription, the DNA sequence
determinants of transcription initiation at a third of human promoters and most enhancers …