DNA replication produces a global disorganization of chromatin structure that takes hours to
be restored. However, how these chromatin rearrangements affect the regulation of gene …

Simple Summary In order for a cell to divide into two cells, it must first copy its DNA. Although
the time required for this process tends not to vary much, many examples of the importance …

Little is known about replication fork velocity variations along eukaryotic genomes, since
reference techniques to determine fork speed either provide no sequence information or …

Chromatin organization is essential to maintain a correct regulation of gene expression and
establish cell identity. However, during cell division, the replication of the genetic material …

Two recent studies in Molecular Cell 1 and Nature 2 show that evicted RNA polymerases
reassociate rapidly with post-replicative chromatin and proceed into an unusual transcription …

Genome duplication occurs through the coordinated action of DNA replication and
nucleosome assembly at replication forks. Defective nucleosome assembly causes DNA …

The discovery of biased histone inheritance in asymmetrically dividing Drosophila
melanogaster male germline stem cells demonstrates one means to produce two distinct …

ABSTRACT DNA replication and RNA transcription both utilize DNA as a template and
therefore need to coordinate their activities. The predominant theory in the field is that in …

Stem cells display asymmetric histone inheritance while non-stem progenitor cells exhibit
symmetric patterns in the Drosophila male germline lineage. Here, we report that …

In eukaryotic chromatin replication, faithful recycling of histones from parental DNA to
replicated leading and lagging strands is essential for maintaining epigenetic information …