Elevated levels of protein kinase CK2 (formerly casein kinase 2 or II) have long been
associated with increased cell growth and proliferation both in normal and cancer cells. The …

The association of protein kinase CK2 (formerly casein kinase II or 2) with cell growth and
proliferation in cells was apparent at early stages of its investigation. A cancer-specific role …

The production of mRNAs in all living organisms is an extremely complex process that
includes multiple catalytic activities such as transcription, capping, splicing, polyadenylation …

Transcription in the nucleus of animal cells is performed by three distinct RNA polymerases
(RNAP), namely RNAPI, RNAPII, and RNAPIII. Among them, RNAPII is responsible for the …

Protein kinase CK2 is a small family of protein kinases that has been implicated in an
expanding array of biological processes. While it is widely accepted that CK2 is a regulatory …

Abstract Cyclin Dependent Kinases (CDKs) represent a large family of serine/threonine
protein kinases that become active upon binding to a Cyclin regulatory partner. CDK/cyclin …

Alternative splicing is a nearly ubiquitous versatile process that controls gene expression
and creates numerous protein isoforms with different functions from a single gene. The …

Protein kinase CK2 (Casein Kinase 2) is an essential, ubiquitous and highly pleiotropic
protein kinase, implicated in several human diseases. In the last decade, several inhibitors …

Although multiple phosphorylation sites are often clustered in substrates, the mechanism of
phosphorylation within clusters has not been systematically investigated. Intriguingly, in …

Specificity is a limiting factor when using small-molecule inhibitors to study protein kinase
signalling. Since inhibitor-resistant kinase mutants (ie, drug-resistant alleles) remain active …