DNA-encoded chemical libraries (DECLs) interrogate the interactions of a target of interest
with vast numbers of molecules. DECLs hence provide abundant information about the …

It is well known that heterocyclic compounds play a key role in improving drug activity, target
selectivity, physicochemical properties as well as reducing toxicity. In this review, we …

We describe the construction of a DNA‐encoded chemical library comprising 148 135
members, generated through the self‐assembly of two sub‐libraries, containing 265 and …

DNA-encoded chemical libraries (DECLs) are increasingly employed in hit discovery toward
proteins of pharmaceutical interest. Protected amino acids are the most commonly used …

Small-molecule chemical probes are crucial tools to study the function of unexplored
proteins in biological systems, thereby directly impacting preclinical target validation. Being …

High-throughput nanomole-scale synthesis allows for late-stage functionalization (LSF) of
compounds in an efficient and economical manner. Here, we demonstrated that copper …

DNA‐encoded libraries (DEL) have come of age and become a major technology platform
for ligand discovery in both academia and the pharmaceutical industry. Technological …

The functionalized 4 H-pyran scaffold has aroused synthetic attention because it is widely
found in many interesting pharmacologically relevant compounds. We here disclose its …

The DNA-encoded chemical library (DEL) technology is a novel drug discovery tool,
benefiting from its large number of compound collections with chemical space coverage …

The DNA-encoded library (DEL) is a powerful hit generation tool for chemical biology and
drug discovery; however, the optimization of DEL hits remained a daunting challenge for the …