Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party

GJ Schuurhuis, M Heuser, S Freeman… - Blood, The Journal …, 2018 - ashpublications.org
Measurable residual disease (MRD; previously termed minimal residual disease) is an
independent, postdiagnosis, prognostic indicator in acute myeloid leukemia (AML) that is …

Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease

JJM Van Dongen, EA Macintyre, JA Gabert… - Leukemia, 1999 - nature.com
Prospective studies on the detection of minimal residual disease (MRD) in acute leukemia
patients have shown that large-scale MRD studies are feasible and that clinically relevant …

High prognostic impact of flow cytometric minimal residual disease detection in acute myeloid leukemia: data from the HOVON/SAKK AML 42A study

M Terwijn, WLJ van Putten, A Kelder… - Journal of clinical …, 2013 - ascopubs.org
Purpose Half the patients with acute myeloid leukemia (AML) who achieve complete
remission (CR), ultimately relapse. Residual treatment-surviving leukemia is considered …

Evaluation of candidate control genes for diagnosis and residual disease detection in leukemic patients using 'real-time'quantitative reverse-transcriptase polymerase …

E Beillard, N Pallisgaard, VHJ Van der Velden, W Bi… - Leukemia, 2003 - nature.com
Real-time quantitative RT-PCR (RQ-PCR) is a sensitive tool to monitor minimal residual
disease (MRD) in leukemic patients through the amplification of a fusion gene (FG) …

Evaluating measurable residual disease in acute myeloid leukemia

F Ravandi, RB Walter, SD Freeman - Blood advances, 2018 - ashpublications.org
Mounting evidence indicates that the presence of measurable (“minimal”) residual disease
(MRD), defined as posttherapy persistence of leukemic cells at levels below morphologic …

Impact of pretransplantation minimal residual disease, as detected by multiparametric flow cytometry, on outcome of myeloablative hematopoietic cell transplantation …

RB Walter, TA Gooley, BL Wood, F Milano… - Journal of clinical …, 2011 - ascopubs.org
Purpose Allogeneic hematopoietic cell transplantation (HCT) benefits many patients with
acute myeloid leukemia (AML) in first remission. Hitherto, little attention has been given to …

Detection of minimal residual disease in hematologic malignancies by real-time quantitative PCR: principles, approaches, and laboratory aspects

VHJ Van der Velden, A Hochhaus, G Cazzaniga… - Leukemia, 2003 - nature.com
Detection of minimal residual disease (MRD) has prognostic value in many hematologic
malignancies, including acute lymphoblastic leukemia, acute myeloid leukemia, chronic …

Bioinspired multivalent DNA network for capture and release of cells

W Zhao, CH Cui, S Bose, D Guo… - Proceedings of the …, 2012 - National Acad Sciences
Capture and isolation of flowing cells and particulates from body fluids has enormous
implications in diagnosis, monitoring, and drug testing, yet monovalent adhesion molecules …

Multiparameter flow cytometric remission is the most relevant prognostic factor for multiple myeloma patients who undergo autologous stem cell transplantation

B Paiva, MB Vidriales, J Cerveró… - Blood, The Journal …, 2008 - ashpublications.org
Minimal residual disease (MRD) assessment is standard in many hematologic malignancies
but is considered investigational in multiple myeloma (MM). We report a prospective …

Residual disease detected by multidimensional flow cytometry signifies high relapse risk in patients with de novo acute myeloid leukemia: a report from Children's …

MR Loken, TA Alonzo, L Pardo… - Blood, The Journal …, 2012 - ashpublications.org
Early response to induction chemotherapy is a predictor of outcome in acute myeloid
leukemia (AML). We determined the prevalence and significance of postinduction residual …