Evolving importance of kidney disease: from subspecialty to global health burden
In the past decade, kidney disease diagnosed with objective measures of kidney damage
and function has been recognised as a major public health burden. The population …
and function has been recognised as a major public health burden. The population …
Vascular calcification: from pathophysiology to biomarkers
The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …
Over time, as clinical importance of this phenomenon has begun to be fully considered …
Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability
AJ King, M Siegel, Y He, B Nie, J Wang… - Science translational …, 2018 - science.org
Hyperphosphatemia is common in patients with chronic kidney disease and is increasingly
associated with poor clinical outcomes. Current management of hyperphosphatemia with …
associated with poor clinical outcomes. Current management of hyperphosphatemia with …
[HTML][HTML] Cisplatin nephrotoxicity as a model of chronic kidney disease
M Shi, KL McMillan, J Wu, N Gillings, B Flores… - Laboratory …, 2018 - Elsevier
Cisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury
(AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported …
(AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported …
Gastrointestinal inhibition of sodium-hydrogen exchanger 3 reduces phosphorus absorption and protects against vascular calcification in CKD
ED Labonté, CW Carreras, MR Leadbetter… - Journal of the …, 2015 - journals.lww.com
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic
cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and …
cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and …
Oxidative stress by Ca2+ overload is critical for phosphate-induced vascular calcification
Hyperphosphatemia is the primary risk factor for vascular calcification, which is closely
associated with cardiovascular morbidity and mortality. Recent evidence showed that …
associated with cardiovascular morbidity and mortality. Recent evidence showed that …
Systematic review and meta-analyses of the effects of phosphate-lowering agents in nondialysis CKD
Background Benefits of phosphate-lowering interventions on clinical outcomes in patients
with CKD are unclear; systematic reviews have predominantly involved patients on dialysis …
with CKD are unclear; systematic reviews have predominantly involved patients on dialysis …
Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway
KK Stevens, L Denby, RK Patel, PB Mark… - Nephrology Dialysis …, 2017 - academic.oup.com
Background Hyperphosphataemia is an independent risk factor for accelerated
cardiovascular disease in chronic kidney disease (CKD), although the mechanism for this is …
cardiovascular disease in chronic kidney disease (CKD), although the mechanism for this is …
Exosomal STAT1 derived from high phosphorus‑stimulated vascular endothelial cells induces vascular smooth muscle cell calcification via the Wnt/β‑catenin signaling …
Z Qin, Y Li, J Li, L Jiang, Z Zhang… - International …, 2022 - spandidos-publications.com
Vascular calcification is commonly observed in chronic kidney disease. The mechanism of
how the calcification signal from endothelial cells is transmitted to vascular smooth muscle …
how the calcification signal from endothelial cells is transmitted to vascular smooth muscle …
Risk factors for heart valve calcification in chronic kidney disease
S Rong, X Qiu, X Jin, M Shang, Y Huang, Z Tang… - Medicine, 2018 - journals.lww.com
Risk factors for heart valve calcification in chronic kidney... : Medicine Risk factors for heart
valve calcification in chronic kidney disease : Medicine Log in or Register Get new issue …
valve calcification in chronic kidney disease : Medicine Log in or Register Get new issue …