Evolving importance of kidney disease: from subspecialty to global health burden

KU Eckardt, J Coresh, O Devuyst, RJ Johnson… - The Lancet, 2013 - thelancet.com
In the past decade, kidney disease diagnosed with objective measures of kidney damage
and function has been recognised as a major public health burden. The population …

Vascular calcification: from pathophysiology to biomarkers

S Evrard, P Delanaye, S Kamel, JP Cristol, E Cavalier… - Clinica chimica acta, 2015 - Elsevier
The link between vascular calcification (VC) and increased mortality is now well established.
Over time, as clinical importance of this phenomenon has begun to be fully considered …

Inhibition of sodium/hydrogen exchanger 3 in the gastrointestinal tract by tenapanor reduces paracellular phosphate permeability

AJ King, M Siegel, Y He, B Nie, J Wang… - Science translational …, 2018 - science.org
Hyperphosphatemia is common in patients with chronic kidney disease and is increasingly
associated with poor clinical outcomes. Current management of hyperphosphatemia with …

[HTML][HTML] Cisplatin nephrotoxicity as a model of chronic kidney disease

M Shi, KL McMillan, J Wu, N Gillings, B Flores… - Laboratory …, 2018 - Elsevier
Cisplatin (CP)-induced nephrotoxicity is widely accepted as a model for acute kidney injury
(AKI). Although cisplatin-induced chronic kidney disease (CKD) in rodent has been reported …

Gastrointestinal inhibition of sodium-hydrogen exchanger 3 reduces phosphorus absorption and protects against vascular calcification in CKD

ED Labonté, CW Carreras, MR Leadbetter… - Journal of the …, 2015 - journals.lww.com
In CKD, phosphate retention arising from diminished GFR is a key early step in a pathologic
cascade leading to hyperthyroidism, metabolic bone disease, vascular calcification, and …

Oxidative stress by Ca2+ overload is critical for phosphate-induced vascular calcification

NT Nguyen, TT Nguyen, D Da Ly… - American Journal …, 2020 - journals.physiology.org
Hyperphosphatemia is the primary risk factor for vascular calcification, which is closely
associated with cardiovascular morbidity and mortality. Recent evidence showed that …

Systematic review and meta-analyses of the effects of phosphate-lowering agents in nondialysis CKD

NM Lioufas, EM Pascoe, CM Hawley… - Journal of the …, 2022 - journals.lww.com
Background Benefits of phosphate-lowering interventions on clinical outcomes in patients
with CKD are unclear; systematic reviews have predominantly involved patients on dialysis …

Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway

KK Stevens, L Denby, RK Patel, PB Mark… - Nephrology Dialysis …, 2017 - academic.oup.com
Background Hyperphosphataemia is an independent risk factor for accelerated
cardiovascular disease in chronic kidney disease (CKD), although the mechanism for this is …

Exosomal STAT1 derived from high phosphorus‑stimulated vascular endothelial cells induces vascular smooth muscle cell calcification via the Wnt/β‑catenin signaling …

Z Qin, Y Li, J Li, L Jiang, Z Zhang… - International …, 2022 - spandidos-publications.com
Vascular calcification is commonly observed in chronic kidney disease. The mechanism of
how the calcification signal from endothelial cells is transmitted to vascular smooth muscle …

Risk factors for heart valve calcification in chronic kidney disease

S Rong, X Qiu, X Jin, M Shang, Y Huang, Z Tang… - Medicine, 2018 - journals.lww.com
Risk factors for heart valve calcification in chronic kidney... : Medicine Risk factors for heart
valve calcification in chronic kidney disease : Medicine Log in or Register Get new issue …