Basic principles of the virulence of Cryptococcus

O Zaragoza - Virulence, 2019 - Taylor & Francis
Among fungal pathogens, Cryptococcus neoformans has gained great importance among
the scientific community of several reasons. This fungus is the causative agent of …

Associations between Cryptococcus Genotypes, Phenotypes, and Clinical Parameters of Human Disease: A Review

MC Montoya, PM Magwene, JR Perfect - Journal of Fungi, 2021 - mdpi.com
The genus Cryptococcus contains two primary species complexes that are significant
opportunistic human fungal pathogens: C. neoformans and C. gattii. In humans …

A re-evaluation of the Chaetothyriales using criteria of comparative biology

Y Quan, L Muggia, LF Moreno, M Wang, AMS Al-Hatmi… - Fungal Diversity, 2020 - Springer
Chaetothyriales is an ascomycetous order within Eurotiomycetes. The order is particularly
known through the black yeasts and filamentous relatives that cause opportunistic infections …

Fungal kinases and transcription factors regulating brain infection in Cryptococcus neoformans

KT Lee, J Hong, DG Lee, M Lee, S Cha, YG Lim… - Nature …, 2020 - nature.com
Cryptococcus neoformans causes fatal fungal meningoencephalitis. Here, we study the
roles played by fungal kinases and transcription factors (TFs) in blood-brain barrier (BBB) …

The cAMP/Protein Kinase A Pathway Regulates Virulence and Adaptation to Host Conditions in Cryptococcus neoformans

M Caza, JW Kronstad - Frontiers in cellular and infection microbiology, 2019 - frontiersin.org
Nutrient sensing is critical for adaptation of fungi to environmental and host conditions. The
conserved cAMP/PKA signaling pathway contributes to adaptation by sensing the …

[HTML][HTML] A fun-guide to innate immune responses to fungal infections

TB Burgess, AM Condliffe, PM Elks - Journal of Fungi, 2022 - mdpi.com
Immunocompromised individuals are at high risk of developing severe fungal infections with
high mortality rates, while fungal pathogens pose little risk to most healthy people. Poor …

Immunomodulatory potential of fungal extracellular vesicles: Insights for therapeutic applications

S Nenciarini, D Cavalieri - Biomolecules, 2023 - mdpi.com
Extracellular vesicles (EVs) are membranous vesicular organelles that perform a variety of
biological functions including cell communication across different biological kingdoms. EVs …

Divergent neuroimmune signatures in the cerebrospinal fluid predict differential gender-specific survival among patients with HIV-associated cryptococcal meningitis

S Okurut, DR Boulware, E Okafor, J Rhein… - Frontiers in …, 2023 - frontiersin.org
Introduction Survival among people with HIV-associated cryptococcal meningitis (CM)
remains low, particularly among women, despite the currently optimal use of antifungal …

The Cryptococcus neoformans Flc1 homologue controls calcium homeostasis and confers fungal pathogenicity in the infected hosts

PR Stempinski, KD Goughenour, LM du Plooy… - Mbio, 2022 - Am Soc Microbiol
Cryptococcus neoformans, an opportunistic yeast pathogen, relies on a complex network of
stress response pathways that allow for proliferation in the host. In Saccharomyces …

Characteristics and potential clinical applications of the extracellular vesicles of human pathogenic Fungi

A Ullah, Y Huang, K Zhao, Y Hua, S Ullah, M Rahman… - BMC microbiology, 2023 - Springer
Extracellular vesicles (EVs) are a heterogeneous group of lipid membrane-enclosed
compartments that contain different biomolecules and are released by almost all living cells …