Taming lupus—a new understanding of pathogenesis is leading to clinical advances
Z Liu, A Davidson - Nature medicine, 2012 - nature.com
Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …
Apoptosis as a mechanism for liver disease progression
ME Guicciardi, GJ Gores - Seminars in liver disease, 2010 - thieme-connect.com
Hepatocyte injury is ubiquitous in clinical practice, and the mode of cell death associated
with this injury is often apoptosis, especially by death receptors. Information from …
with this injury is often apoptosis, especially by death receptors. Information from …
Structural basis of CpG and inhibitory DNA recognition by Toll-like receptor 9
U Ohto, T Shibata, H Tanji, H Ishida, E Krayukhina… - Nature, 2015 - nature.com
Innate immunity serves as the first line of defence against invading pathogens such as
bacteria and viruses. Toll-like receptors (TLRs) are examples of innate immune receptors …
bacteria and viruses. Toll-like receptors (TLRs) are examples of innate immune receptors …
Intrinsic danger: activation of Toll-like receptors in rheumatoid arthritis
FG Goh, KS Midwood - Rheumatology, 2012 - academic.oup.com
RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …
inflammation leading to progressive joint destruction. Recent advances in the molecular …
TLR7 induces anergy in human CD4+ T cells
M Dominguez-Villar, AS Gautron, M De Marcken… - Nature …, 2015 - nature.com
The recognition of microbial patterns by Toll-like receptors (TLRs) is critical for activation of
the innate immune system. Although TLRs are expressed by human CD4+ T cells, their …
the innate immune system. Although TLRs are expressed by human CD4+ T cells, their …
Telomeric repeat-containing RNA (TERRA) constitutes a nucleoprotein component of extracellular inflammatory exosomes
Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated
regulator of chromosome end protection. Here, we report that TERRA can also be found in …
regulator of chromosome end protection. Here, we report that TERRA can also be found in …
Biomarkers predicting sepsis in polytrauma patients: Current evidence
V Ciriello, S Gudipati, PZ Stavrou, NK Kanakaris… - Injury, 2013 - Elsevier
Introduction Major trauma still represents one of the leading causes of death in the first four
decades of life. Septic complications represent the predominant causes of late death (45 …
decades of life. Septic complications represent the predominant causes of late death (45 …
Design, synthesis and biological evaluation of novel antagonist compounds of Toll-like receptors 7, 8 and 9
ER Kandimalla, L Bhagat, D Wang, D Yu… - Nucleic acids …, 2013 - academic.oup.com
Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif
act as antagonists of Toll-like receptor (TLR) 7 and TLR9. In the present study, we designed …
act as antagonists of Toll-like receptor (TLR) 7 and TLR9. In the present study, we designed …
Cell-free fetal DNA, telomeres, and the spontaneous onset of parturition
M Phillippe - Reproductive sciences, 2015 - journals.sagepub.com
Multiple previous reports have provided compelling support for the premise that
spontaneous parturition is mediated by activation of inflammation-related signaling …
spontaneous parturition is mediated by activation of inflammation-related signaling …
[HTML][HTML] Extracellular Nucleic Acids Present in the Candida albicans Biofilm Trigger the Release of Neutrophil Extracellular Traps
M Smolarz, M Zawrotniak, D Satala… - Frontiers in Cellular …, 2021 - frontiersin.org
Neutrophils, the first line of the host's defense, use a variety of antimicrobial mechanisms to
fight invading pathogens. One of the most crucial is the production of neutrophil extracellular …
fight invading pathogens. One of the most crucial is the production of neutrophil extracellular …