Systemic lupus erythematosus (SLE) is an autoimmune disease that is characterized by the
loss of tolerance to nuclear self antigens, the production of pathogenic autoantibodies and …

Hepatocyte injury is ubiquitous in clinical practice, and the mode of cell death associated
with this injury is often apoptosis, especially by death receptors. Information from …

Innate immunity serves as the first line of defence against invading pathogens such as
bacteria and viruses. Toll-like receptors (TLRs) are examples of innate immune receptors …

RA is a debilitating disorder that manifests as chronic localized synovial and systemic
inflammation leading to progressive joint destruction. Recent advances in the molecular …

The recognition of microbial patterns by Toll-like receptors (TLRs) is critical for activation of
the innate immune system. Although TLRs are expressed by human CD4+ T cells, their …

Telomeric repeat-containing RNA (TERRA) has been identified as a telomere-associated
regulator of chromosome end protection. Here, we report that TERRA can also be found in …

Introduction Major trauma still represents one of the leading causes of death in the first four
decades of life. Septic complications represent the predominant causes of late death (45 …

Oligonucleotides containing an immune-stimulatory motif and an immune-regulatory motif
act as antagonists of Toll-like receptor (TLR) 7 and TLR9. In the present study, we designed …

Multiple previous reports have provided compelling support for the premise that
spontaneous parturition is mediated by activation of inflammation-related signaling …

Neutrophils, the first line of the host's defense, use a variety of antimicrobial mechanisms to
fight invading pathogens. One of the most crucial is the production of neutrophil extracellular …