Alzheimer's disease (AD) was described in 1906 as a dementing disease marked by the
presence of two types of fibrillar aggregates in the brain: neurofibrillary tangles and senile …

Autosomal dominant Alzheimer's disease (ADAD) offers a unique opportunity to study
pathophysiological changes in a relatively young population with few comorbidities. A …

The prevalence of Alzheimer's disease (AD) and its associated economic and societal
burdens are on the rise, but there are no curative treatments for AD. Interestingly, this …

Aging is accompanied by deterioration in physical condition, and creates high risks of
diseases. Stem cell therapy exhibited promising potential in delaying aging. However, the …

Insulin resistance underlies Alzheimer's disease (AD) by affecting neuroinflammation and
brain-derived neurotrophic factor (BDNF) expression. Here, we evaluated the effect of early …

Importance With the emergence of new therapeutics for treatment of Alzheimer's disease,
there is currently a critical need for sensitive and accurate blood-based tests to assist with …

In recent years, the study of sex difference in Alzheimer's disease (AD) has been a rapidly
increasing topic of research. Men and women have distinct variances in terms of disease …

Hyperphosphorylation and aggregation of the microtubule binding protein tau plays a key
role in the development of Alzheimer's disease. While the structure of the filamentous …

Strong evidence indicates that insulin resistance contributes to the development of
Alzheimers disease by promoting inflammation, oxidative stress, and blood vessel damage …

Diagnostika Alzheimerovy nemoci je v současné době založena na stanovení přítomnosti
specifických proteinů v cerebrospinální tekutině (CSF), případně jejich zobrazení pomocí …