Protein network analysis and functional studies of calcium oxalate crystal‐induced cytotoxicity in renal tubular epithelial cells

P Peerapen, S Chaiyarit, V Thongboonkerd - Proteomics, 2018 - Wiley Online Library
Our previous expression study has reported a set of proteins with altered levels in renal
tubular cells after exposure to calcium oxalate monohydrate (COM) crystals, which are the …

[HTML][HTML] ATF5 regulates tubulointerstitial injury in diabetic kidney disease via mitochondrial unfolded protein response

Y Liu, L Zhang, S Zhang, J Liu, X Li, K Yang, D Yang… - Molecular …, 2023 - Springer
Background Mitochondrial quality control (MQC) plays a critical role in the progression of
tubulointerstitial injury in diabetic kidney disease (DKD). The mitochondrial unfolded protein …

[HTML][HTML] High glucose induces phosphorylation and oxidation of mitochondrial proteins in renal tubular cells: A proteomics approach

S Aluksanasuwan, S Plumworasawat, T Malaitad… - Scientific Reports, 2020 - nature.com
Mitochondrial dysfunction has been thought to play roles in the pathogenesis of diabetic
nephropathy (DN). However, precise mechanisms underlying mitochondrial dysfunction in …

[HTML][HTML] Epigallocatechin-3-gallate plays more predominant roles than caffeine for inducing actin-crosslinking, ubiquitin/proteasome activity and glycolysis, and …

PEM Gallemit, S Yoodee, T Malaitad… - Biomedicine & …, 2021 - Elsevier
A recent expression proteomics study has reported changes in cellular proteome (set of
proteins) of human endothelial cells (ECs) induced by caffeine and epigallocatechin-3 …

[HTML][HTML] Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission

XL Wang, QQ Zhu, A Simayi, GP Xu - Open Medicine, 2023 - degruyter.com
Mitochondrial dysfunction and oxidative stress are considered to be two main drivers of
diabetic myocardial ischemia-reperfusion injury (DM+ MIRI). Nuclear factor-erythroid 2 …

An untargeted metabolomic strategy based on liquid chromatography-mass spectrometry to study high glucose-induced changes in HK-2 cells

S Bernardo-Bermejo, E Sánchez-López… - … of Chromatography A, 2019 - Elsevier
Diabetes mellitus is a major health concern nowadays. It is estimated that 40% of diabetics
are affected by diabetic nephropathy, one of the complications derived from high glucose …

Calcium oxalate monohydrate crystal disrupts tight junction via F-actin reorganization

P Peerapen, V Thongboonkerd - Chemico-Biological Interactions, 2021 - Elsevier
Tight junction is an intercellular protein complex that regulates paracellular permeability and
epithelial cell polarization. This intercellular barrier is associated with actin filament. Calcium …

[HTML][HTML] A non-targeted capillary electrophoresis-mass spectrometry strategy to study metabolic differences in an in vitro model of high-glucose induced changes in …

S Bernardo-Bermejo, E Sánchez-López… - Molecules, 2020 - mdpi.com
Diabetic nephropathy is characterized by the chronic loss of kidney function due to high
glucose renal levels. HK-2 proximal tubular cells are good candidates to study this disease …

Increased osmolality enhances the tight junction‐mediated barrier function in a cultured renal epithelial cell line

LP Canuto, CB Collares‐Buzato - Cell biology international, 2019 - Wiley Online Library
Osmotic alterations are associated with several human diseases, including diabetic
nephropathy. We have previously shown that high glucose, which is a well‐known osmotic …

Nrf2 protects against myocardial ischemia-reperfusion injury in diabetic rats by inhibiting Drp1-mediated mitochondrial fission

W Xiao-Li, Z Qian-Qian, A Simayi, GP Xu - Open Medicine, 2023 - search.proquest.com
Mitochondrial dysfunction and oxidative stress are considered to be two main drivers of
diabetic myocardial ischemia-reperfusion injury (DM+ MIRI). Nuclear factor-erythroid 2 …