[HTML][HTML] Glycosaminoglycans and glycosaminoglycan mimetics in cancer and inflammation

S Morla - International journal of molecular sciences, 2019 - mdpi.com
Glycosaminoglycans (GAGs) are a class of biomolecules expressed virtually on all
mammalian cells and usually covalently attached to proteins, forming proteoglycans. They …

The dual role of the glycosaminoglycan chondroitin‐6‐sulfate in the development, progression and metastasis of cancer

A Pudełko, G Wisowski, K Olczyk… - The FEBS Journal, 2019 - Wiley Online Library
The remarkable structural heterogeneity of chondroitin sulfate (CS) and dermatan sulfate
(DS) generates biological information that can be unique to each of these …

Silk fibroin-chondroitin sulfate scaffold with immuno-inhibition property for articular cartilage repair

F Zhou, X Zhang, D Cai, J Li, Q Mu, W Zhang, S Zhu… - Acta biomaterialia, 2017 - Elsevier
The demand of favorable scaffolds has increased for the emerging cartilage tissue
engineering. Chondroitin sulfate (CS) and silk fibroin have been investigated and reported …

Functionalised penetrating peptide-chondroitin sulphate‑gold nanoparticles: Synthesis, characterization, and applications as an anti-Alzheimer's disease drug

Y Feng, X Li, D Ji, J Tian, Q Peng, Y Shen… - International Journal of …, 2023 - Elsevier
The purpose of this study was to construct a transmembrane peptide-chondroitin sulphate‑
gold nanoparticle (TAT-CS@ Au) delivery system and investigate its activity as an anti …

Anti-inflammatory activity of chondroitin sulphate: new functions from an old natural macromolecule

N Volpi - Inflammopharmacology, 2011 - Springer
Chondroitin sulphate (CS) is recommended by the European League Against Rheumatism
as a symptomatic slow-acting drug for the treatment of osteoarthritis on the basis of …

Sulfated glycans in inflammation

VH Pomin - European journal of medicinal chemistry, 2015 - Elsevier
Sulfated glycans such as glycosaminoglycans on proteoglycans are key players in both
molecular and cellular events of inflammation. They participate in leukocyte rolling along the …

Honokiol inhibits the inflammatory reaction during cerebral ischemia reperfusion by suppressing NF-κB activation and cytokine production of glial cells

P Zhang, X Liu, Y Zhu, S Chen, D Zhou, Y Wang - Neuroscience letters, 2013 - Elsevier
This study was designed to investigate the effects of honokiol, a neuroprotective agent, on
cerebral edema in cerebral ischemia reperfusion (IR) mice and its mechanism of anti …

Oral chondroprotection with nutraceuticals made of chondroitin sulphate plus glucosamine sulphate in osteoarthritis

C Bottegoni, RAA Muzzarelli, F Giovannini… - Carbohydrate …, 2014 - Elsevier
Oral supplementation of chondroitin sulphate plus glucosamine helps repair the articular
surface in osteoarthritis. Chondroitin-S reduces the concentration of the pro-inflammatory …

Preparation and in vitro evaluation of multi-target-directed selenium-chondroitin sulfate nanoparticles in protecting against the Alzheimer's disease

F Gao, J Zhao, P Liu, D Ji, L Zhang, M Zhang… - International journal of …, 2020 - Elsevier
The purpose of this study was to ascertain the effect of selenium-chondroitin sulfate
nanoparticles (CS@ Se) on multi-target-directed therapy for the treatment of Alzheimer's …

[HTML][HTML] Chondroitin sulphate inhibits NF-κB activity induced by interaction of pathogenic and damage associated molecules

TV Stabler, Z Huang, E Montell, J Verges… - Osteoarthritis and …, 2017 - Elsevier
Objective To evaluate the anti-inflammatory mechanism of action of Chondroitin Sulphate
(CS). Design THP-1 macrophages were cultured with a range of sizes and concentrations of …