The unprecedented speed of delivery of SARS-CoV-2 pandemic vaccines has redefined the
limits for all vaccine development. Beyond the aspirational 100-day timeline for tomorrow's …

Critical knowledge gaps regarding infection with Mycobacterium ulcerans, the cause of
Buruli ulcer (BU), have impeded development of new therapeutic approaches and vaccines …

For any controlled human infection model (CHIM), a safe, standardized, and biologically
relevant challenge inoculum is necessary. For hepatitis C virus (HCV) CHIM, we propose …

Infectious diseases continue to account for a significant portion of global deaths despite the
use of vaccines for several centuries. Immunization programs around the world are a …

Invasive non-typhoidal Salmonella disease (iNTS) is a major cause of morbidity and
mortality globally, particularly as a cause of bloodstream infection in children and …

Background Due to antibiotic resistance, the Klebsiella genus is linked to morbidity and
death, necessitating the development of a universally protective vaccine against Klebsiella …

Introduction Invasive non-typhoidal Salmonella (iNTS) serovars are a major cause of
community-acquired bloodstream infections in sub-Saharan Africa (SSA). In this setting …

Tuberculosis remains a formidable global health challenge, causing substantial morbidity
and mortality due to the limited protection in the lungs provided by the current BCG vaccine …

Background Early host immunity to acute respiratory infections (ARIs) is heterogenous,
dynamic, and critical to an individual's infection outcome. Due to limitations in sampling …

The leishmaniases are globally important parasitic diseases for which no human vaccines
are currently available. To facilitate vaccine development, we conducted an open label …