Regulation of the RNA polymerase II pre-initiation complex by its associated coactivators
S Malik, RG Roeder - Nature Reviews Genetics, 2023 - nature.com
Abstract The RNA polymerase II (Pol II) pre-initiation complex (PIC) is a critical node in
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …
eukaryotic transcription regulation, and its formation is the major rate-limiting step in …
Eukaryotic core promoters and the functional basis of transcription initiation
Abstract RNA polymerase II (Pol II) core promoters are specialized DNA sequences at
transcription start sites of protein-coding and non-coding genes that support the assembly of …
transcription start sites of protein-coding and non-coding genes that support the assembly of …
Eukaryotic cell size control and its relation to biosynthesis and senescence
The most fundamental feature of cellular form is size, which sets the scale of all cell
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
biological processes. Growth, form, and function are all necessarily linked in cell biology, but …
Structural insights into preinitiation complex assembly on core promoters
INTRODUCTION RNA polymerase II (Pol II)–mediated transcription initiation requires
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
assembly of a preinitiation complex (PIC), during which the 14-subunit transcription factor IID …
Structures of the human Mediator and Mediator-bound preinitiation complex
INTRODUCTION The multisubunit Mediator binds RNA polymerase II (Pol II), transduces
regulatory signals from transcription factors to Pol II, facilitates preinitiation complex (PIC) …
regulatory signals from transcription factors to Pol II, facilitates preinitiation complex (PIC) …
Structures of+ 1 nucleosome–bound PIC-Mediator complex
RNA polymerase II–mediated eukaryotic transcription starts with the assembly of the
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …
preinitiation complex (PIC) on core promoters. The+ 1 nucleosome is well positioned about …
[HTML][HTML] Simple biochemical features underlie transcriptional activation domain diversity and dynamic, fuzzy binding to Mediator
AL Sanborn, BT Yeh, JT Feigerle, CV Hao… - Elife, 2021 - elifesciences.org
Gene activator proteins comprise distinct DNA-binding and transcriptional activation
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …
domains (ADs). Because few ADs have been described, we tested domains tiling all yeast …
[HTML][HTML] SAGA is a general cofactor for RNA polymerase II transcription
T Baptista, S Grünberg, N Minoungou, MJE Koster… - Molecular cell, 2017 - cell.com
Prior studies suggested that SAGA and TFIID are alternative factors that promote RNA
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …
polymerase II transcription, with about 10% of genes in S. cerevisiae dependent on SAGA …
Assessing sufficiency and necessity of enhancer activities for gene expression and the mechanisms of transcription activation
RR Catarino, A Stark - Genes & development, 2018 - genesdev.cshlp.org
Enhancers are important genomic regulatory elements directing cell type-specific
transcription. They assume a key role during development and disease, and their …
transcription. They assume a key role during development and disease, and their …
RNA polymerase II dynamics and mRNA stability feedback scale mRNA amounts with cell size
MP Swaffer, GK Marinov, H Zheng, LF Valenzuela… - Cell, 2023 - cell.com
A fundamental feature of cellular growth is that total protein and RNA amounts increase with
cell size to keep concentrations approximately constant. A key component of this is that …
cell size to keep concentrations approximately constant. A key component of this is that …