Cell therapy: types, regulation, and clinical benefits

AEH El-Kadiry, M Rafei, R Shammaa - Frontiers in Medicine, 2021 - frontiersin.org
Cell therapy practices date back to the 19th century and continue to expand on
investigational and investment grounds. Cell therapy includes stem cell-and non–stem cell …

Cross-talk between cancer stem cells and immune cells: potential therapeutic targets in the tumor immune microenvironment

B Wu, X Shi, M Jiang, H Liu - Molecular Cancer, 2023 - Springer
Ongoing research has revealed that the existence of cancer stem cells (CSCs) is one of the
biggest obstacles in the current cancer therapy. CSCs make an influential function in tumor …

Cancer stem cells: A review from origin to therapeutic implications

MR Atashzar, R Baharlou, J Karami… - Journal of cellular …, 2020 - Wiley Online Library
Cancer stem cells (CSCs), also known as tumor‐initiating cells (TICs), are elucidated as
cells that can perpetuate themselves via autorestoration. These cells are highly resistant to …

microRNAs in cancer management

YW Kong, D Ferland-McCollough, TJ Jackson… - The lancet …, 2012 - thelancet.com
Since the identification of microRNAs (miRNAs) in 1993, and the subsequent discovery of
their highly conserved nature in 2000, the amount of research into their function …

Is CD47 an innate immune checkpoint for tumor evasion?

X Liu, H Kwon, Z Li, Y Fu - Journal of Hematology & Oncology, 2017 - Springer
Abstract Cluster of differentiation 47 (CD47)(also known as integrin-associated protein) is a
ubiquitously expressed glycoprotein of the immunoglobulin superfamily that plays a critical …

Rewiring cell polarity signaling in cancer

R Halaoui, L McCaffrey - Oncogene, 2015 - nature.com
Disrupted cell polarity is a feature of epithelial cancers. The Crumbs, Par and Scribble
polarity complexes function to specify and maintain apical and basolateral membrane …

Cell membrane camouflaged nanoparticles: a new biomimetic platform for cancer photothermal therapy

M Wu, W Le, T Mei, Y Wang, B Chen… - International journal of …, 2019 - Taylor & Francis
Targeted drug delivery by nanoparticles (NPs) is an essential technique to achieve the ideal
therapeutic effect for cancer. However, it requires large amounts of work to imitate the …

The immune microenvironment and cancer metastasis

A El-Kenawi, K Hänggi… - Cold Spring …, 2020 - perspectivesinmedicine.cshlp.org
The dynamic interplay between neoplastic cells and the immune microenvironment
regulates every step of the metastatic process. Immune cells contribute to invasion by …

ALDH1A1 maintains ovarian cancer stem cell-like properties by altered regulation of cell cycle checkpoint and DNA repair network signaling

E Meng, A Mitra, K Tripathi, MA Finan, J Scalici… - PloS one, 2014 - journals.plos.org
Objective Aldehyde dehydrogenase (ALDH) expressing cells have been characterized as
possessing stem cell-like properties. We evaluated ALDH+ ovarian cancer stem cell-like …

Hypoxia-inducible factor 1 alpha promotes cancer stem cells-like properties in human ovarian cancer cells by upregulating SIRT1 expression

J Qin, Y Liu, Y Lu, M Liu, M Li, J Li, L Wu - Scientific reports, 2017 - nature.com
Ovarian cancer have a poor overall survival rate in patients, and late disease presentation
and chemoresistance are the main factors that lead to the mortality of ovarian cancer …