BACKGROUND AND OBJECTIVES: The majority of cancer patients suffer from chronic
anemia. While recombinant human erythropoietin (rHuEPO) offers many of the advantages …

Basophils are rare, circulating leukocytes derived from hematopoietic CD34+ progenitors.
The identification of cytokines promoting their development in vitro has led to substantial …

The classical model of hematopoiesis predicts a dichotomous lineage restriction of
multipotent hematopoietic progenitors (MPPs) into common lymphoid progenitors (CLPs) …

The molecular components which mediate cytokine signaling from the cell membrane to the
nucleus were studied. Upon the interaction of cytokines with their receptors, members of the …

OBJECTIVE: Erythropoiesis is positively regulated by stem cell factor, interleukin 3, and
erythropoietin, which synergize to allow the production of hemoglobinized red blood cells …

Autoimmunity is often implicated in pure red-cell aplasia. Approximately 10 to 15 percent of
patients with pure red-cell aplasia have thymomas, 1 and remission of the anemia occurs in …

Systemic mastocytosis (SM) is a rare disease caused by an abnormal mast cell
accumulation in various tissues. Two classes of constitutive activating c-kit mutations are …

Thrombopoietin (TPO) is a newly cloned cytokine which is the major regulator of circulating
platelet levels, acting on both proliferation and differentiation of megakaryocytes. We have …

Background. The treatment of uraemic patients with recombinant human erythropoietin
(rHuEpo) often leads to an increase in blood pressure. Indirect and direct effects of the …

This review summarizes the changes in cell surface antigen expression during proliferation
and differentiation of human erythroid progenitors. The content is based on our experimental …