The renin–angiotensin system is an important component of the cardiovascular system.
Mounting evidence suggests that the metabolic products of angiotensin I and II—initially …

Despite the success of renin-angiotensin system (RAS) blockade by angiotensin-converting
enzyme (ACE) inhibitors and angiotensin II type 1 receptor (AT1R) blockers, current …

Over the years, coronaviruses (CoV) have posed a severe public health threat, causing an
increase in mortality and morbidity rates throughout the world. The recent outbreak of a …

This article provides a contemporary review and a new perspective on the role of neprilysin
inhibition in heart failure (HF) in the context of recent clinical trials and addresses potential …

Diabetic kidney disease develops in approximately 40% of diabetic patients and is a major
cause of chronic kidney diseases (CKD) and end stage kidney disease (ESKD) worldwide …

Increasing evidence supports a role of proximal tubular (PT) injury in the progression of
diabetic kidney disease (DKD), in patients with or without proteinuria. Research on the …

The recent emergence of coronavirus disease-2019 (COVID-19) as a global pandemic has
prompted scientists to address an urgent need for defining mechanisms of disease …

Diabetic kidney disease (DKD) is one of the main causes of end-stage renal disease
(ESRD) and all-cause mortality in diabetic patients, despite the extensive use of angiotensin …

Background Diabetic nephropathy (DN) is among the most common microvascular
complications of diabetes resulting in end-stage renal disease and therefore search for …

Aims The present study aimed at exploring the mechanisms behind Klotho regulation in
hyperglycemia augmented AKI. In addition, epigenetic ways to restore the Klotho expression …